Kidney- and Site-Selective Delivery of 5-Fluorouracil Utilizing the Absorption on the Kidney Surface in Rats
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概要
- 論文の詳細を見る
The present study was undertaken to elucidate the kidney- and site-selective delivery of 5-fluorouracil (5-FU) utilizing the absorption on the kidney surface in rats. An experimental system utilizing a cylindrical diffusion cell attached to the right kidney surface was established. After intravenous administration of 5-FU, the concentration of 5-FU in the right and left kidneys was almost the same and was rapidly eliminated. After right kidney surface application of 5-FU, however, the concentration of 5-FU in the right kidney was significantly higher than in the left kidney and other tissues. The 5-FU concentration in four sites of the right kidney after intravenous administration was almost the same. In contrast, 5-FU was site selectively delivered in the kidney after kidney surface application. The blood concentration of 5-FU was low (<1.7 μg/ml) until 120 min after kidney surface application. The maximum blood concentration of 5-FU after kidney surface application was much lower than after intravenous administration.
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
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中島 幹夫
佐賀大学医学部附属病院 手術部
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Murakami T
Kyoto Univ. Kyoto
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Kawakami Shigeru
京都大学 薬学研究科
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Kawakami Shigeru
Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Sugahara Yazuyuki
長崎大学 医歯薬学総合研究科臨床検査医学講座
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中村 純三
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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SAKAEDA Toshiyuki
Department of Hospital Pharmacy, Kobe University School of Medicine
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Sugahara Yazuyuki
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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NAKASHIMA Mikiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
School Of Pharmaceutical Sciences Nagasaki University
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Nishida K
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima Mikiro
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakaeda Toshiyuki
筑波大学 人間総合科学研究科
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Murakami T
National Inst. Advanced Industrial Sci. And Technol. Ibaraki
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Horimoto Tomomi
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Hara Shintaro
長崎大学 医学部第二内科
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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HIRAYAMA Ryu
Graduate School of Biomedical Sciences, Nagasaki University
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Sakanaka Koji
参天製薬奈良研究開発センター
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Hirayama Ryu
Graduate School Of Biomedical Sciences Nagasaki University
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Tomonari Masahide
参天製薬奈良研究開発センター
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Mukai T
九州大学 大学院薬学研究院
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Mukai Takahiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukai Takahiro
京都大学 薬学研究科病態機能分析学
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Mukai Takahiro
Graduate School Of Medicine Kyoto University
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Nakano M
Department Of Laboratory Medicine Nagasaki University School Of Medicine
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Mori Tomohiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Sasaki Hitoshi
長崎大学 医歯学部病院薬剤部
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy Kobe University Hospital
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KAWAKAMI Shigeru
School of Pharmaceutical Sciences, Nagasaki University
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HORIMOTO Tomomi
School of Pharmaceutical Sciences, Nagasaki University
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NISHIDA Koyo
School of Pharmaceutical Sciences, Nagasaki University
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HIRAYAMA Ryu
School of Pharmaceutical Sciences, Nagasaki University
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MUKAI Takahiro
School of Pharmaceutical Sciences, Nagasaki University
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Kashiwagi Satsuki
School Of Pharmaceutical Sciences Nagasaki University
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Sakanaka Koji
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry:santen Pharma
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Mukuno Takashi
The Graduate School Of National Science And Technology Okayama University
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Nakashima Mikiro
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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