Ascorbate Analogs for Use in Medical Imaging : Synthesis and Radical Scavenging Activity of 5-O-(4'-Iodobenzyl)-L-ascorbic Acid
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概要
- 論文の詳細を見る
As part of our program to develop potential imaging agents for ascorbate bioactivity in the brain, 5-O-(4'-iodobenzyl)-L-ascorbic acid was prepared through a seven-step sequence which involved C_5-O-alkylation with p-iodobenzyl bromide in the presence of Ag_2O and CaSO_4 as the key step, starting from L-ascorbic acid. The scavenging activity of the p-iodobenzylated analog against 2, 2-diphenyl-1-picrylhyrazyl (DPPH) radical was almost the same as that of L-ascorbic acid itself.
- 社団法人日本薬学会の論文
- 2007-12-01
著者
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Murakami T
Kyoto Univ. Kyoto
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Murakami T
National Inst. Advanced Industrial Sci. And Technol. Ibaraki
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MUKAI Takahiro
Graduate School of Biomedical Sciences, Nagasaki University
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Tomonari Masahide
参天製薬奈良研究開発センター
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Mukai T
九州大学 大学院薬学研究院
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Mukai Takahiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukai Takahiro
京都大学 薬学研究科病態機能分析学
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Mukai Takahiro
Graduate School Of Medicine Kyoto University
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YAMAMOTO Fumihiko
Graduate School of Pharmaceutical Sciences, Kyushu University
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MAEDA Minoru
Graduate School of Pharmaceutical Sciences, Kyushu University
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KATO Hiroharu
Graduate School of Pharmaceutical Sciences, Kyushu University
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KINO Tomohiro
Graduate School of Pharmaceutical Sciences, Kyushu University
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KANESHIRO Tetsuo
Graduate School of Pharmaceutical Sciences, Kyushu University
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Mori Tomohiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Kato Hiroharu
Graduate School Of Pharmaceutical Sciences Kyushu University
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Kino Tomohiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Kaneshiro Tetsuo
Graduate School Of Pharmaceutical Sciences Kyushu University
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Maeda Minoru
Optical Measurement Technology Development Co. Ltd.
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Maeda Minoru
Graduate School Of Pharmaceutical Sciences Kyushu University
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Yamamoto Fumihiko
Graduate School Of Pharmaceutical Sciences Kyushu University:crest Japan Sceicne And Technology Corp
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Yamamoto Fumihiko
Graduate School Of Pharmaceutical Sciences Kyushu University
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Maeda M
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukuno Takashi
The Graduate School Of National Science And Technology Okayama University
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Maeda Minoru
Graduate School Of Pharmaceutical Sciences Kyushu Univ.
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Yamamoto Fumihiko
Graduate School of Pharmaceutical Sciences
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Maeda Minoru
Graduate School of Pharmaceutical Sciences
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