Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study was undertaken to elucidate the stomach- and site-selective delivery of 5-fluorouracil (5-FU) following its application on the gastric serosal surface in rats. An experimental system utilizing a cylindrical diffusion cell attached to the gastric serosal surface was established. To evaluate the gastric distribution of 5-FU, the stomach was separated into the site under the diffusion cell (site 1) and the site not under the diffusion cell (site 2). Furthermore, the mucosal side at site 1 was separated from the serosal side. After intravenous and oral administration of 5-FU, the 5-FU concentrations at sites 1 and 2 until 240 min were similar. After gastric serosal surface application of 5-FU, however, the concentration of 5-FU at site 1 until 240 min was approximately 10-fold higher than that at site 2, and was sustained. Furthermore, the 5-FU concentration on the mucosal side at site 1 and the serosal side at site 1 were comparable after gastric serosal surface application. The blood concentration of 5-FU was low (<4.4 μg/ml) until 240 min after gastric serosal surface application. The maximum blood concentration of 5-FU after gastric serosal surface application was significantly lower than after intravenous administration. Thus, the stomach- and site-selective delivery system following application on the gastric serosal surface could be applied with anticancer drugs for the treatment of gastric cancer.
- 社団法人日本薬学会の論文
- 2005-06-01
著者
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中島 幹夫
佐賀大学医学部附属病院 手術部
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中島 幹夫
佐賀医科大学手術部
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Murakami T
Kyoto Univ. Kyoto
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中村 純三
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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NAKASHIMA Mikiro
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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Nakamura J
Faculty Of Pharmaceutical Sciences Nagasaki University
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Nakamura Junzo
長崎大学 薬
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Nakamura Junzo
School Of Pharmaceutical Sciences Nagasaki University
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Nishida K
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Dep. Of Clinical Pharmacy Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima M
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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Nakashima Mikiro
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Fumoto Shintaro
京都大学 薬学研究科薬品動態制御学
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Murakami T
National Inst. Advanced Industrial Sci. And Technol. Ibaraki
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Sasaki H
Dep. Of Hospital Pharmacy Nagasaki Univ. Hospital
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NISHI JUNYA
Graduate School of Biomedical Sciences, Nagasaki University
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FUMOTO SHINTARO
Graduate School of Biomedical Sciences, Nagasaki University
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NAKAMURA JUNZO
Graduate School of Biomedical Sciences, Nagasaki University
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NISHIDA KOYO
Graduate School of Biomedical Sciences, Nagasaki University
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KOBAYASHI Kazuko
Graduate School of Biomedical Sciences, Nagasaki University
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MUKAI Takahiro
Graduate School of Biomedical Sciences, Nagasaki University
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Kawazu Kouichi
Santen Pharmaceutical Co. Ltd. Nara Research And Development Center
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Tomonari Masahide
参天製薬奈良研究開発センター
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Mukai T
九州大学 大学院薬学研究院
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Mukai Takahiro
Graduate School Of Pharmaceutical Sciences Kyushu University
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Mukai Takahiro
京都大学 薬学研究科病態機能分析学
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Mukai Takahiro
Graduate School Of Medicine Kyoto University
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Nakano M
Department Of Laboratory Medicine Nagasaki University School Of Medicine
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Mori Tomohiko
Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University
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Sasaki Hitoshi
長崎大学 医歯学部病院薬剤部
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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Shiota H
Nagasaki Univ. Nagasaki Jpn
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Sasaki Hajime
Semiconductor Group Mitsubishi Electric Corporation
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Sasaki Hideyuki
R&d Center Toshiba Corp.
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Kobayashi Kazuko
Santen Pharmaceutical Co. Ltd. Nara Research And Development Center
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Sasaki H
Central Research Laboratories Zeria Pharmaceutical Co. Ltd.
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Sasaki H
Electrotechnical Laboratory
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Mukuno Takashi
The Graduate School Of National Science And Technology Okayama University
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Sasaki H
Nagasaki Univ. School Of Medicine Nagasaki Jpn
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Nishida Koyo
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Sasaki Hitoshi
Department Of Hospital Pharmacy Nagasaki University Hospital
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Fumoto Shintaro
Graduate School Of Biomedical Sciences Nagasaki Univ.
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Nakashima Mikiro
Department of Clinical Pharmacy, Graduate School of Biomedical Sciences, Nagasaki University
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