Change in Erythrocyte Shape Induced by Cyclosporine Administration
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概要
- 論文の詳細を見る
In order to estimate the effect of the long term administration of cyclosporine (CsA) on the shape change of erythorocytes, erythorocyte shapes which are observed with a scanning electron microscope were classfieid according to the nomenclature of Bessis for stomatocyte-echinocyte shape transformation. As a result of observing the erythrocyte shape of fifty-six patients with kidney transplantation treated with CsA, the morphological index of the erythrocytes of patients significantly increased to 0.0835±0.0085^<***> in comparison with 0.0004±0.0051 of those from healthy volunteers (control) (*** : p<0.001,ANOVA). Such transformations had no relation to the subject's sex or age. On the other hand, the erythrocytes of patients administered more than 100 ng/ml of CsA and posttransplanted within less than two years were transformed by CsA from the state of discocyte to echinocyte. In rats, the morphological index of erythrocytes of rats treated with 3 mg/kg/d or 5 mg/kg/d of CsA significantly increased in comparison with rats treated with saline (control). Furthermore, the erythrocytes of two patients were observed in terms of shape before the treatment with CsA. In both patients, the echinocyte type of erythrocyte increased by treatment with CsA. In vitro, the morphological index of the erythrocytes incubated with plasma containing CsA significantly increased, to 0.459±0.066^<***> in comparison with 0.064±0.029 of the control. It is suggested from these results that CsA treatment induces the echinocyte type of erythrocyte.
- 公益社団法人日本薬学会の論文
- 1998-11-15
著者
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SASAKI Hitoshi
Department of Hospital Pharmacy, Nagasaki University Hospital of Medicine and Dentistry
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To Hideto
長崎大学 医歯学部病院薬剤部
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To Hideto
Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry
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To Hideto
Department Of Pharmaceutics Daiichi College Of Pharmaceutical Sciences
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ICHIKAWA Masataka
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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Hirai Masami
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Hirai Masami
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Sasaki Hitoshi
Department Of Basic Pharmaceutics Faculty Of Pharmaceutical Sciences Kyoto University
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NAKASHIMA Tomoki
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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Sasaki H
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Saito Yoshihiro
Department Of Bio-analytical Chemistry Osaka University Of Pharmaceutical Sciences
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OHSAKO Masahiko
Department of Pharmaceutics, Daiichi College of Pharmaceutical Sciences
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NAKAMURA Chitose
Department of Pharmaceutics, Daiichi College of Pharmaceutical Sciences
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YAMADA Misato
Department of Pharmaceutics, Daiichi College of Pharmaceutical Sciences
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TSUZUKI Osami
Department of Pharmaceutics, Daiichi College of Pharmaceutical Sciences
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TATSUO Emi
Department of Hospital Pharmacy Nagasaki University School of Medicine
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MATSUYA Fukuzo
Urology, Nagasaki University School of Medicine
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SAITO Yutaka
Urology, Nagasaki University School of Medicine
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Nakashima Tomoki
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Nakashima Tomoki
Department Of Cell Signaling Graduate School Tokyo Medical And Dental University And Coe Program For
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Saito Y
Tohoku Pharmaceutical Univ. Sendai Jpn
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Tsuzuki O
Department Of Pharmaceutics Daiichi College Of Pharmaceutical Sciences
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Yamada Misato
Department Of Pharmaceutics Daiichi College Of Pharmaceutical Sciences
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Yamada Misato
Department Of Bioengineering Soka University
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Matsuya Fukuzo
Urology Nagasaki University School Of Medicine
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Nakamura C
Showa College Of Pharmaceytical Sciences
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Ohsako Masahiko
Department Of Pharmaceutics Daiichi College Of Pharmaceutical Sciences
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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Nakashima T
Kyoto Prefectural Univ. Medicine Kyoto Jpn
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Nakashima Tomoki
Department Of Cell Signaling Graduate School Tokyo Medical And Dental University
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To Hideto
Department Of Hospital Pharmacy Nagasaki University Hospital
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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Tsuzuki Osami
Department of Pharmaceutics, Daiichi College of Pharmaceutical Science
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ICHIKAWA MASATAKA
Department of Chemical Engineering, Kyushu University
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