Determination of γ-Aminobutyric Acid and Associated Amino Acids in Mouse Brain by Liquid Chromatography
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概要
- 論文の詳細を見る
A rapid method is described for the analysis of amino acids containing in mouse brain by high performance liquid chromatography equipped with a fluorescence detector. Pre-column o-phthaladehyde-2-mercaptoethanol derivatives of the amino acids were injected onto an ODS C-18 column. 5-Amino-n-valeric acid, a non-endogenous amino acid, was used as an internal standard. Separation and elution of amino acid derivatives were achieved by varying the ratio of organic phase by a step gradient. Significant increases in γ-aminobutyric acid, glutamine and glycine levels in the brain were detected 2 h after injection of 800 mg/kg valproic acid (VPA). A high dose administration of VPA was correlated with Reye's syndrome.
- 公益社団法人日本薬学会の論文
著者
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ICHIKAWA Masataka
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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Ichikawa M
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Matsuyama Kenji
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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GOTO SHIGERU
Faculty of Pharmaceutical Sciences, Okayama University
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Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Matsuyama Kenji
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Goto S
Faculty Of Pharmaceutical Sciences Kyushu University
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Miyazaki C
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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Goto Shigeru
Faculty Of Pharmaceutical Science Kyushu University
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Goto Shigeru
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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ICHIKAWA MASATAKA
Department of Chemical Engineering, Kyushu University
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