Acquisition of Drug Resistance to Imipenem and Other Newer Beta-Lactams by Pseudomonas aeruginosa
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概要
- 論文の詳細を見る
In Pseudomonas aeruginosa strains treated with ceftizoxime and latamoxef, the frequency of appearance of highly resistant strains from parent strains was 10^<-5> to 10^<-8>. In the case of ceftazidime, highly resistant strains developed from moderately resistant strains at a frequency of about 10^<-8>. On the other hand, no strain acquired a high resistance to imipenem or aztreonam, but moderately resistant strains developed from parent strains at a frequency of 10^<-5> to 10^<-8>. In a study of the mechanisms of resistance, strains highly resistant to ceftizoxime, latamoxef and ceftazidime had derepressed production of beta-lactamase, while parent strains produced inducible beta-lactamase. Imipenem-resistant strains had unchanged patterns of beta-lactamase production, but these strains had an outer membrane protein with a different molecular weight from that of the parent strain(48,000 daltons). Cross-resistance was not observed between imipenem-resistant strains and other beta-lactam-resistant strains.
- 日本医療薬学会の論文
- 1992-10-20
著者
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ISHII Yoshikazu
Department of Microbiology, Toho University School of Medicine
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Kaku Mitsuo
Clinical Laboratory Department Nagasaki University Hospital
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Ishii Yoshikazu
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Ishii Yoshikazu
Department Of Oral Histology Nagasaki University School Of Dentistry
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ICHIKAWA MASATAKA
Pharmacy Department, Nagasaki University Hospital
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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