Acquisition of Resistance to Beta-Lactams by Enterobacter cloacae and Serratia marcescens in the Clinical Field
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概要
- 論文の詳細を見る
We compared the drug resistance patterns of clinical isolates of Enterobacter cloacae and Serratja marcescens in 1983 and 1990 at Nagasaki University Hospital. Furthermore, beta-lactamase production by drug-resistant strains of several organisms was investigated. In 1990, the number of E. cloacae or S. marcescens strains isolated was about half of that in 1983. Most of the E. cloacae strains were isolated from the respiratory tract in both years. A large proportion of S. marcescens strains were isolated from the urinary tract in 1983, but in 1990 these strains were isolated from the respiratory tract. An increase in E. cloacae strains and S. marcescens strains resistant to ceftizoxime or to latamoxef was not noted when com paring 1990 with 1983. The beta-lactamase prepared from resistant strains isolated in 1990 showed a higher potency than that from susceptible strains isolated in the same year, and a larger amount of betalactamase was produced by the resistant strains. Beta-lactamase production by resistant strains of E. cloacae, Citrobacter freundii, and S. marcescens was found to be due to derepression. These strains resistant to beta-lactams were susceptible to imipenem.
- 日本医療薬学会の論文
- 1992-10-20
著者
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ISHII Yoshikazu
Department of Microbiology, Toho University School of Medicine
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Usui Toshiaki
Clinical Laboratory Nagasaki University Hospital
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Kaku Mitsuo
Clinical Laboratory Department Nagasaki University Hospital
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Ishii Yoshikazu
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Ishii Yoshikazu
Department Of Oral Histology Nagasaki University School Of Dentistry
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ICHIKAWA MASATAKA
Pharmacy Department, Nagasaki University Hospital
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SHIMOGUCHI KAZUNORI
Clinical Laboratory, Nagasaki University Hospital
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YASUMURA YUKIE
Pharmacy Department, Nagasaki University Hospital
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Shimoguchi Kazunori
Clinical Laboratory Nagasaki University Hospital
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Shimoguchi Kazunori
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Yasumura Yukie
Pharmacy Department Nagasaki University Hospital
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Ichikawa Masataka
Department Of Hospital Pharmacy Nagasaki University School Of Medicine
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Ichikawa Masataka
Department Of Pharmacy Nagasaki University Hospital
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ICHIKAWA MASATAKA
Department of Hospital Pharmacy, Nagasaki University School of Medicine
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