Evaluation of Camellia sinensis Catechins as a Swine Antimicrobial Feed Additive that does not Cause Antibiotic Resistance
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概要
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Antimicrobial growth promoters (AGPs) have been banned and phased out because their use has been linked to the emergence and spread of antibiotic-resistant pathogens; however, the ban has had a marked impact on livestock production, and feed additive alternatives to AGPs are required. We focused on green tea leaves as potential alternatives to AGPs because they contain significant amounts of polyphenol catechins, which have antivirus and antimicrobial effects. We examined cross-resistance between epigallocatechin gallate (EGCG), which is the most abundant catechin of green tea leaves, and commercially available antimicrobials in clinically problematic antimicrobial-resistant bacteria, and whether bacteria have the ability to acquire resistance by consecutive passage in sub-inhibitory concentrations of EGCG. EGCG did not display any cross-resistance with reference antimicrobials and the bacteria did not acquire EGCG resistance. Further, we examined the growth-promoting effects of dried green tea leaves on the breeding of a new Japanese breed, Tokyo-X pigs. While the mortality rates of the green tea leaf (GTL) and AGP groups were both 11.1% (one in nine piglets), the mortality rate was 50% for the control group with an additive-free diet (four in eight piglets). The rate of body weight increase in both the GTL and AGP groups was approximately the same. The growth-promoting effects of green tea leaves and AGPs were similar, and there was no possibility that the antimicrobial properties of catechins caused the same problem as AGPs. Thus, it can be concluded that green tea leaves are a safe feed additive alternative to AGPs.
著者
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Tateda Kazuhiro
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Ishii Yoshikazu
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Ohno Akira
Department Of Bioresources Chemistry Faculty Of Agriculture Okayama University
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Yamaguchi Keizo
Department Of Clinical Laboratory Nagasaki University Hospital
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OHNO Akira
Department of Microbiology and Infectious Diseases, School of Medicine, Faculty of Medicine, Toho University
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Tateda Kazuhiro
Department of Microbiology and Infectious Diseases, School of Medicine, Faculty of Medicine, Toho University
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Kataoka Shinichiro
Animal Science Division, Tokyo Metropolitan Agriculture and Forestry Research Center
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Terasaki Toshiaki
Animal Science Division, Tokyo Metropolitan Agriculture and Forestry Research Center
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Kiso Masaaki
Animal Science Division, Tokyo Metropolitan Agriculture and Forestry Research Center
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Okubo Mitsuyuki
Animal Science Division, Tokyo Metropolitan Agriculture and Forestry Research Center
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Ishii Yoshikazu
Department of Microbiology and Infectious Diseases, School of Medicine, Faculty of Medicine, Toho University
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