Comparison of clinical and radiological features of pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases: A multicenter study
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概要
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Background: The clinical features of pneumocystis pneumonia (PCP) differ according to the predisposing factors responsible for immunosuppression. Although PCP in patients with acquired immunodeficiency syndrome (AIDS) has been extensively described, its characteristics in non-AIDS patients, such as those with malignancies, are not thoroughly documented. Study objective: To characterize and compare the clinical and imaging features of PCP in patients with malignancies with those in AIDS patients. Design: A multi-center retrospective study. Patients and Measurements: We evaluated the clinical and radiological features of PCP in 21 patients with malignancies and in 17 with AIDS. Clinical presentation, serum markers, oxygenation, CT findings, and outcome were examined. Results: The patients with malignancies showed shorter durations of symptoms before PCP was diagnosed. The levels of serum markers and the oxygenation index did not differ. CT showed diffuse or widespread ground-glass opacity (GGO) in all of the patients evaluated. None of the AIDS patients demonstrated consolidation, whereas half of the patients with malignancy showed consolidation along with GGO. The extent of GGO scored on CT images was significantly greater in the AIDS patients. No correlation was observed between the CT findings and other clinical parameters. All of the AIDS patients recovered from PCP, whereas six patients with malignancies died within a month after the onset of PCP. Conclusion: The characteristics of the CT images differed between the patient groups with different underlying disorders, although it remains to be determined whether CT findings are associated with other clinical features or are predictive of the outcome of PCP. © 2010 The Japanese Society of Internal Medicine.
著者
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Yasui Masahide
Respiratory Medicine Cellular Transplantation Biology Kanazawa University Graduate School Of Medicin
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JOHKOH TAKESHI
Department of Medical Physics, Osaka University Graduate School of Medicine
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Tateda Kazuhiro
Department Of Microbiology And Infectious Disease Toho University School Of Medicine
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Goto Hajime
Department of Respiratory Medicine, Kyorin University School of Medicine
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Sakai Fumikazu
Department of Diagnostic Radiology, Saitama International Medical Center, Saitama Medical University
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Tokuda Hitoshi
Department Of Internal Medicine Social Insurance Central General Hospital
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Kikuchi Yoshimi
Division Of Aids Research Center International Medical Center Of Japan
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Ohta Hiromitsu
Department Of Mechanical Engineering National Fishery University
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Tasaka Sadatomo
Division Of Pulmonary Medicine Department Of Medicine Keio University School Of Medicine
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Araoka Hideki
Department Of Infectious Diseases Toranomon Hospital
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Johkoh Takeshi
Department of Radiology, Kinki Central Hospital
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Yasui Masahide
Division of Respiratory Medicine, Kanazawa Municipal Hospital
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Ohmagari Norio
Division of Infectious Diseases, Shizuoka Cancer Center
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Goto Hajime
AIDS Clinical Center, International Medical Center of Japan
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Inuzuka Kanako
Department of Respiratory Medicine, Kyorin University School of Medicine
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SAKAI Fumikazu
Department of Diagnostic Radiology, International Medical Center, Saitama Medical University
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Johkoh Takeshi
Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine
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