Mycophenolate mofetil is effective and well tolerated in the treatment of refractory acute and chronic graft-versus-host disease
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概要
- 論文の詳細を見る
We enrolled 11 patients with refractory graft-versus-host disease (GVHD) in a prospective trial evaluating the efficacy of mycophenolate mofetil (MMF). Four (67%) of the 6 patients with acute GVHD and all 5 patients with chronic GVHD responded to MMF. Ten (91%) of the 11 patients were able to decrease steroid use (median decrease, 86%; range, 25%-l00%). After a median follow-up of 18 months (range, 1-65 months), 7 patients (64%) remained alive. The adverse events were infectious complications (36%), diarrhea (27%), and neutropenia (18%); the only patient discontinuing MMF did so because of grade 4 neutropenia. This preliminary study suggests that MMF is a well-tolerated agent and has a beneficial effect in the treatment of refractory acute and chronic GVHD. ©2006 The Japanese Society of Hematology.
- 日本血液学会 = Japanese Society of Hematologyの論文
- 2006-01-15
著者
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OKUMURA Hirokazu
Department of Hematology, Kanazawa University Graduate School of Medical Science
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中尾 眞二
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
日本医科大学 第三内科
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高見 昭良
金沢大学大学院医学系研究科細胞移植学
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YAMAZAKI Masahide
Department of Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa Univer
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ASAKURA Hidesaku
Department of Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa Univer
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NAKAO Shinji
Department of Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa Univer
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TAKAMI Akiyoshi
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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MOCHIZUKI Kanako
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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ITO Satsuki
Department of Pharmacy, Kanazawa University Graduate School of Medicine
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SUGA Yukio
Department of Pharmacy, Kanazawa University Graduate School of Medicine
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YAMAZAKI Hirohito
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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KONDO Yukio
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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KAMI Masahiro
Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital
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Yasui Masahide
金沢大学 医学系研究科細胞移植学
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Yasui Masahide
Respiratory Medicine Cellular Transplantation Biology Kanazawa University Graduate School Of Medicin
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Yasui M
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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Okumura Hirokazu
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Okumura Hirokazu
日本医科大学 第三内科
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Okumura H
Kanazawa Univ. Graduate School Of Medical Sci. Jpn
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Yasui Masahide
Department Of Cellular Transplantation Biology Graduate School Of Medical Sciences Kanazawa Universi
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Yasui Masahide
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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Nakao Shinji
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Scienc
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Nakao Shinji
Department Of Hematology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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Takami Akiyoshi
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Takami Akiyoshi
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medicine
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朝倉 英策
金沢大学附属病院高密度無菌治療部
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Nakao Shinji
Cellular Transplantation Biology Department Of Respiratory Medicine Kanazawa University Graduate Sch
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Kadohira Yasuko
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Asakura H
Department Of Internal Medicine (iii) Kanazawa University School Of Medicine
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Yamazaki Masahide
Department Of Cellular Transplantation Biology Graduate School Of Medical Sciences Kanazawa Universi
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Okumura Hirokazu
Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn
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Okumura Hirokazu
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Scienc
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Sano Yoko
Department Of Hospital Pharmacy Kanazawa University School Of Medicine
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Ito Satsuki
Department Of Pharmacy Kanazawa University Graduate School Of Medicine
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Shirafuji Naoki
Department Of Hematology/oncology Teikyo University School Of Medicine
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Sahara Naohi
Department Of Internal Medicine Iii Hamamatsu University School Of Medicine
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Yamauchi H
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Mochizuki Kanako
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medicine
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Ito Satsuki
Department of Hospital Pharmacy, Kanazawa University School of Medicine
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Suga Yukio
Department of Clinical Drug Informatics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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