Nonspecific interstitial pneumonia with abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune disease
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概要
- 論文の詳細を見る
Recently, great attention has been drawn to IgG4-related diseases such as autoimmune pancreatitis (AIP) sclerosing sialadenitis, retroperitoneum fibrosis, sclerosing cholangitis. IgG4-related diseases are characterized by high serum IgG4 concentrations, sclerosing inflammation with numerous IgG4-positive plasma cells, and steroid sensitivity irrespective of their organs of origin. In this report, we describe a case of nonspecific interstitial pneumonia, in which possible involvement of IgG4 was suggested. The patient was 59-year-old man, who was found to have bilateral interstitial pneumonia. Laboratory tests revealed that he had antinuclear antibody and a high serum IgG4 concentration. Pathological examination of the video-assisted thoracic surgery biopsy taken from the right lower lobe showed interstitial thickening associated with lymphoplasmacytic infiltration containing many IgG4-positive plasma cells. He was effectively treated by corticosteroid. The present case had many clinical and clinicopathologic similarities to systemic IgG4-related autoimmune disease. There have been no descriptions on isolated interstitial pneumonia with IgG4-positive plasma cell infiltration. This case suggested that IgG4-related disorders could also occur in the lung, and interstitial pneumonia may be a pulmonary manifestation of systemic IgG4-related autoimmune disease © 2008 The Japanese Society of Internal Medicine.
- 日本内科学会 = Japanese Society of Internal Medicineの論文
著者
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NAKAO Shinji
Department of Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa Univer
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ZEN Yoh
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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Zen Yoh
福井県済生会病院 放射線診断部
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Takato Hazuki
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate S
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Yasui Masahide
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate S
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Ichikawa Yukari
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate S
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Fujimura Masaki
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate S
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Minato Hiroshi
Department of Pathology and Laboratory Medicine, Kanazawa Medical University
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Yasui Masahide
Department Of Cellular Transplantation Biology Graduate School Of Medical Sciences Kanazawa Universi
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Zen Yoh
Department Of Diagnostic Pathology Kanazawa University Graduate School Of Medicine
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Nakao Shinji
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Scienc
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Minato Hiroshi
Department Of Electrical Engineering And Computer Science Tufts University
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Fujimura Masaki
Department Of Gynecology Saitama Cancer Center
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Fujimura Masaki
Pulmonary Medicine Cellular Transplantation Biology Kanazawa Graduate School Of Medicine
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藤村 政樹
金沢大学大学院医学系研究科細胞移植学・呼吸器内
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Takato Hazuki
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Yasui Masahide
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Ichikawa Yukari
Department of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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