Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis

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• We report the case of a 65-year-old man with recurrent prostate cancer who presented with meningeal carcinomatosis. In September 2007, he had been diagnosed with mixed type small cell carcinoma and adenocarcinoma at clinical stage T4N1M1 (primary prostate tumor with multiple bone, liver, and lymph node metastases) and hormonal therapy had been administered. Following an increase in the level of pro-gastrin-releasing peptide (ProGRP), combined chemotherapy with cisplatin plus etoposide was implemented and showed efficacy in targeting the small cell carcinoma. In March 2008, he presented with signs of meningeal irritation; his condition deteriorated quickly and multiple brain metastases were confirmed by magnetic resonance imaging (MRI). A sample of cerebrospinal fluid collected by lumbar puncture showed cancer cells and an elevated level of ProGRP. Small cell carcinoma of the prostate complicated with meningeal carcinomatosis was diagnosed. A different chemotherapy regimen was then administered, consisting of a combination of carboplatin plus irinotecan, which is one of the most common first-line treatments for extensive-stage small cell lung carcinoma. From day 20 after the initiation of this therapy, he gradually recovered from the signs of meningeal irritation, and brain MRI showed nearly normal findings; also, the serum level of ProGRP was reduced. In conclusion, we report the efficacy of combined treatment with carboplatin plus irinotecan for small cell carcinoma of the prostate complicated with meningeal carcinomatosis. Because this clinical condition is extremely rare, a gold standard treatment has yet to be established. © 2009 Japan Society of Clinical Oncology.

• 2009-10-01

著者

• 渡邊 弘之

  Department Of Internal Medicine And Medical Oncology Cancer Research Institute Kanazawa University

• Zen Yoh

  Department Of Diagnostic Pathology Kanazawa University Hospital

• Zen Yoh

  Department Of Diagnostic Pathology Kanazawa University Graduate School Of Medicine

• Watanabe Hiroyuki

  Department Of Internal Medicine And Medical Oncology Cancer Research Institute Kanazawa University

• Yano Seiji

  Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences Universit

• Yamashita Kaname

  Department Of Surgical Oncology Cancer Research Institute Kanazawa University

• YAMADA Tadaaki

  Kanazawa University Hospital Cancer Center

• OHTSUBO Koushiro

  Kanazawa University Hospital Cancer Center

• MOURI Hisatsugu

  Kanazawa University Hospital Cancer Center

• YAMASHITA Kaname

  Kanazawa University Hospital Cancer Center

• YASUMOTO Kazuo

  Kanazawa University Hospital Cancer Center

• IZUMI Kouji

  Kanazawa University Hospital Cancer Center

• WATANABE Hiroyuki

  Kanazawa University Hospital Cancer Center

• YANO Seiji

  Kanazawa University Hospital Cancer Center

• Zen Yoh

  Department Of Human Pathology Kanazawa University Graduate School Of Medical Science

• 大坪 公士郎

  Department Of Internal Medicine And Medical Oncology Cancer Research Institute Kanazawa University

• Yano S

  Department Of Internal Medicine And Molecular Therapeutics University Of Tokushima School Of Medicin

• YAMASHITA Kaname

  Cancer Center, Kanazawa University

• 毛利 久継

  Cancer Center Kanazawa University

• Yamashita Kaname

  Cancer Center Kanazawa University

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