Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib

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概要

• 論文の詳細を見る

• We report the case of a 67-year-old man with metastatic papillary renal cell carcinoma (RCC) who developed bloody sputum after the administration of sunitinib. Chest computed tomography revealed diffuse ground-glass opacity lesions, and bloody bronchoalveolar lavage fluid was obtained by flexible bronchoscopy. The abnormal shadows promptly regressed after withdrawal of sunitinib. In four cycles of sunitinib treatment, he suffered from controllable diffuse alveolar hemorrhage. Finally, he died of respiratory failure 8 months after onset. This is the first case report of diffuse alveolar hemorrhage as an adverse effect of sunitinib in metastatic papillary RCC. Care should be taken with pulmonary hemorrhage in the use of anti-angiogenesis agents in not only squamous cell lung cancer, but also metastatic lung tumors. © 2010 Japan Society of Clinical Oncology.

• Springer Verlag (Germany)の論文
• 2010-12-01

著者

• Yano Seiji

  The Third Department Of Internal Medicine Tokushima University School Of Medicine

• KITAGAWA Satoshi

  Department of Human Pathology, Kanazawa University Graduate School of Medical Science

• Yano Seiji

  Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences Universit

• Yamashita Kaname

  Department Of Surgical Oncology Cancer Research Institute Kanazawa University

• Yamada Tadaaki

  Department Of Internal Medicine And Molecular Therapeutics Institute Of Health Biosciences Universit

• YAMADA Tadaaki

  Kanazawa University Hospital Cancer Center

• YASUMOTO Kazuo

  Kanazawa University Hospital Cancer Center

• IZUMI Kouji

  Kanazawa University Hospital Cancer Center

• YANO Seiji

  Kanazawa University Hospital Cancer Center

• 大坪 公士郎

  Department Of Internal Medicine And Medical Oncology Cancer Research Institute Kanazawa University

• Yano S

  Department Of Internal Medicine And Molecular Therapeutics University Of Tokushima School Of Medicin

• YAMADA Tadaaki

  Cancer Center, Kanazawa University

• OHTSUBO Koushiro

  Cancer Center, Kanazawa University

• IZUMI Kouji

  Cancer Center, Kanazawa University

• TAKEUCHI Shinji

  Cancer Center, Kanazawa University

• MOURI Hisatsugu

  Cancer Center, Kanazawa University

• YAMASHITA Kaname

  Cancer Center, Kanazawa University

• YASUMOTO Kazuo

  Cancer Center, Kanazawa University

• GHENEV Peter

  Cancer Center, Kanazawa University

• YANO Seiji

  Cancer Center, Kanazawa University

• 毛利 久継

  Cancer Center Kanazawa University

• Izumi Kouji

  Cancer Center Kanazawa University

• Yasumoto Kazuo

  Cancer Center Kanazawa University

• Yamada Tadaaki

  Cancer Center Kanazawa University

• Ghenev Peter

  Cancer Center Kanazawa University

• Yano Seiji

  Cancer Center Kanazawa University

• Kitagawa Satoshi

  Department Of Molecular And Cellular Pathology Kanazawa University

• Kitagawa Satoshi

  Department Of Bioscience Fukui Prefectural University

• Yamashita Kaname

  Cancer Center Kanazawa University

• Takeuchi Shinji

  Cancer Center Kanazawa University

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