Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis
スポンサーリンク
概要
- 論文の詳細を見る
Aim: Serum antinuclear antibodies (ANA) are occasionally noted in patients with non-alcoholic steatohepatitis (NASH). We examined the significance of ANA in NASH. Methods: We compared clinicopathological features in patients with ANA-positive NASH (n = 35) and ANA-negative NASH (n = 36). Inflammatory cell profiles and the distribution of oxidative stress markers were also examined immunohistochemically. Results: ANA-positive NASH was significantly associated with female gender (P = 0.005), high degree of portal inflammation (P = 0.039), interface activity (P = 0.036) and hepatocellular ballooning (P = 0.0008). In addition, ANA of high titer (320-fold or more) was significantly associated with the histological grade and stage of NASH (P = 0.02). The degree of steatosis wais rather mild in the high-titer ANA group(P = 0.01). The analysis of inflammatory cell profiles revealed that CD3-positive T cells were predominant and plasma cells were rather few in the portal area and hepatic lobules in both ANA-positive and ANA-negative groups. There was no difference in the distribution of oxidative stress markers between ANA-positive and ANA-negative groups. Conclusion: These findings suggest that the presence of ANA may be related to the progression of NASH and that a different type of autoimmune mechanism may be involved in the pathogenesis of NASH with ANA, compared to the pathogenesis of autoimmune hepatitis. © 2007 The Japan Society of Hepatology.
- Elsevierの論文
- 2007-11-01
著者
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Uchiyama Akio
Department of Pathology, Toyama Prefectural Central Hospital
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Miwa Atsuo
Department of Pathology, Toyama Prefectural Central Hospital
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中沼 安二
金沢大学医学系研究科形態機能病理学
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中沼 安二
金沢大学大学院医学系研究科形態機能病理学
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HARATAKE Joji
Department of Pathology and Clinical Laboratories, Saiseikai Yahata Hospital
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SASAKI Motoko
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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NAKANUMA Yasuni
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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Minato Hiroshi
Pathology Section, Kanazawa University Hospital
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Zen Yoh
Department Of Diagnostic Pathology Kanazawa University Hospital
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NIWA Hideki
Department of Human Pathology, Kanazawa University Graduate School of Medicine
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KASAI Takahiko
Department of Diagnostic Pathology, Nara Medical University
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KATAYANAGI Kazuyoshi
Department of Pathology, Ishikawa Prefectural Central Hospital
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KURUMAYA Hiroshi
Department of Pathology, Ishikawa Prefectural Central Hospital
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MASUDA Shinji
Department of Pathology, Kouseiren Takaoka Hospital
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ZEN You
Pathology Section, Kanazawa University Hospital
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SAITO Katsuhiko
Department of Pathology, Toyama City Hospital
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SUDO Yoshiko
Department of Pathology, Fukui Saiseikai Hospital
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Nakanuma Yasuni
金沢大学 医学系研究科形態機能病理学教室
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Nakanuma Yasuni
金沢大学がん研究所 腫瘍内科
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Naruse Y
School Of Nursing Toyama University
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Naruse Yuchi
Fac. Of Medicine School Of Nursing Toyama Univ.
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Sasaki M
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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Sasaki Motoko
Department Of Pathology (ii) Kanazawa University School Of Medicine
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Sakurai Masaru
Dep. Of Epidemiology And Public Health Kanazawa Medical Univ.
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Kurumaya Hiroshi
Department Of Pathology Ishikawa Prefectural Central Hospital
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Zen Yoh
Pathology Section Kanazawa University Hospital
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Zen Yoh
Pathology Division Kanazawa University Hospital
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Nakanuma Yasuni
2nd Department Of Pathology School Of Medicine Kanazawa University
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Sasaki Motoko
Department Of Human Pathology Kanazawa University Graduate School Of Medical Science
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Sasaki Motoko
Department Of Biology Faculty Of Science Nara Women's University
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Matsuda Shinji
Department Of Biology Faculty Of Pharmaceutical Sciences Hoshi University
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ZEN Yoh
Diagnostic Pathology Division of Kanazawa University Hospital
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Haratake Joji
Department Of Pathology And Clinical Laboratories Saiseikai Yahata Hospital
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Nakanishi Yoshitsugu
北海道大学 医学研究科消化器内科
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Minato Hiroshi
Pathology Section Kanazawa University Hospital
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Minato Hiroshi
Pathology Division Kanazawa University Hospital
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Nakanuma Yasuni
Department Of Pathology School Of Medicine Kanazawa University
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Sakurai Masaru
The Department Of Endocrinology And Metabolism (first Department Of Internal Medicine) Kanazawa Univ
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Masuda Shinji
Department Of Biology Tokyo Metropolitan University
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Nagao Yasuyuki
Third Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakatsuji Yoshiyuki
Department Of Pediatrics Shinshu University School Of Medicine
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Kasai Takahiko
Department Of Diagnostic Pathology Nara Medical University
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Uchiyama Akio
Department Of Clinical Pathology Toyama Prefectural Central Hospital
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Miwa Atsuo
Department Of Gastroenterology Aichi Cancer Center Hospital
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Katayanagi Kazuyoshi
Department Of Human Pathology Graduate School Of Medicine Kanazawa University
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Nakamura Yasuni
Second Department Of Pathology Kanazawa University School Of Medicine.
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Sudo Yoshiko
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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Sudo Yoshiko
Department Of Pathology Fukui Saiseikai Hospital
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Nakanuma Yasuni
Department Of Human Pathology Graduate School Of Medicine Kanazawa University
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Zen You
Pathology Section Kanazawa University Hospital
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Miyakawa Hiroshi
Department Of Medicine (iv) Teikyou University School Of Medicine Mizonokuchi Hospital
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Saito Katsuhiko
Department Of Pathology Toyama City Hospital
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Nakanishi Yoshitsugu
Department Of Surgical Oncology Division Of Cancer Medicine Hokkaido University Graduate School Of M
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Sasaki Masatoshi
Kanazawa And Department Of Surgery Saiseikai Takaoka Hospital
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Niwa Hideki
Department Of Human Pathology Kanazawa University Graduate School Of Medicine
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Nakanuma Yasuni
Department Of Human Pathology Graduate School Of Medical Science Kanazawa University
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Haratake Joji
Department Of Diagnostic Pathology Saiseikai Yahata General Hospital
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Nakayama Yoshiko
Department Of Pediatrics Shinshu University School Of Medicine
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Saito Katsuhiko
Department of Electrical and Electronic Engineering, Synchrotron Light Application Center, Saga University, Saga 840-8502, Japan
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Miwa Atsuo
Department of Clinical Pathology, Toyama Prefectural Central Hospital
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