原発性胆汁性肝硬変(23例)の肝内胆管系に関する組織計測学的検索

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A new method was presented for morphometrical examination of the intrahepatic bile ducts designed upon a view that the hepatic arterial branches and the bile ducts run parallel in the portal tiad. The present experiment was carried out using the method to know the level and extent of the intrahepatic bile duct destruction in the livers of PBC. It was shown that in PBC livers (23 cases) the bile ducts with diameter below approximately 70-80 μ were destructed and the smaller the duct, the more the destruction. The destruction of intrahepatic bile ducts was neither so extensive in the 1st stage of PBC nor progressive in further stage of PBC, even in cirrhotic liver. <BR>It was suggested that this marked destruction of intrahepatic bile duct (especially smaller bile ducts) might be an important factor for occurrence of chronic intrahepatic cholestasis and apparently progressive and fatal course of PBC.
社団法人日本肝臓学会の論文