Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.
スポンサーリンク
概要
- 論文の詳細を見る
A 53-year-old postmenopausal woman, who had a family history of cryptogenic liver cirrhosis, was diagnosed with osteoporosis, and started on the selective estrogen receptor modulator (SERM) raloxifene 60 mg/day orally. She developed marked liver dysfunction. Her body mass index (BNU) was 26.5. Her blood chemistry indicated AST 342 IU/L, ALT 356 IU/L, and hyaluronic acid 255 ng/mL. An oral glucose tolerance test showed impaired glucose tolerance with marked insulin resistance. Histologically, we diagnosed this case as having pre-cirrhotic nonalcoholic steatohepatitis (NASH). This is the first histologically confirmed case of NASH that was aggravated by raloxifene. © 2007 The Japanese Society of Internal Medicine.
- 日本内科学会の論文
著者
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Kaneko Shuichi
Department Of Disease Control And Homeostasis Kanazawa University Graduate School Of Medical Science
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Takamura Toshinari
Department Of Endocrinology And Metabolism Kanazawa University Graduate School Of Medical Science
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Matsushita Eiki
Department of Internal Medicine, Kahoku Central Hospital
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Zen Yoh
福井県済生会病院 放射線診断部
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Minato Hiroshi
Pathology Section, Kanazawa University Hospital
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ZEN Yoh
Pathology Division, Kanazawa University Hospital
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ANDO HITOSHI
Department of Disease Control and Homeostacis, Kanazawa University Graduate School of Medical Scienc
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Takamura Toshinari
Department Of Diabetes And Digestive Disease Kanazawa University Graduate School Of Medical Science
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Shimizu Akiko
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Scienc
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Komura Takuya
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Scienc
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Zen Yoh
Pathology Division Kanazawa University Hospital
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Minato Hiroshi
Pathology Division Kanazawa University Hospital
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Ando Hitoshi
Department Of Biomaterials Science Faculty Of Dentistry Tokyo Medical And Dental University
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Kaneko Shuichi
Department Of Cancer Gene Regulation Kanazawa University
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Matsushita Eiki
Department Of Internal Medicine (i) School Of Medicine Kanazawa University
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Shimizu Akiko
Department Of Bioengincering Facutly Of Engineering Soka University
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TAKAMURA Toshinari
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
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Zen Yoh
Pathology Section, Kanazawa University Hospital
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