Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus
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概要
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A 57-year-old man was admitted to our hospital complaining of poor appetite. He had been diagnosed with diabetes mellitus and was anti-GAD antibody (GAD-Ab) negative 1 year previously, at the age of 56 years old. Abdominal CT revealed pancreas tail swelling; elastase-I level was elevated and he was diagnosed with pancreatitis. The level of GAD-Ab was increased and HLA haplotype was DRB1*0901-DQB1*0303, which is seen frequently in type 1 diabetic Japanese patients. However, his endogenous insulin secretion ability was not deteriorated. After elastase-I level and pancreas swelling improved, GAD-Ab returned to a normal range. One year after the onset of pancreas swelling, he was still not in an insulin-dependent state. In this case, transient GAD-Ab positivity with susceptible haplotype for type 1 diabetes mellitus might have been induced by a GAD antigen discharged from the destroyed islet due to pancreatitis. © 2009 The Japanese Society of Internal Medicine.
- The Japanese Society of Internal Medicine = 日本内科学会の論文
著者
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Takamura Toshinari
Department Of Endocrinology And Metabolism Kanazawa University Graduate School Of Medical Science
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Takamura Toshinari
河北中央病院(国民健康保険) 内科
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Kahara Toshio
Department of Internal Medicine, Kahoku Central Hospital
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Otoda Toshiki
Department of Internal Medicine, Kahoku Central Hospital
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Ishikura Kazuhide
Department of Internal Medicine, Kahoku Central Hospital
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Matsushita Eiki
Department of Internal Medicine, Kahoku Central Hospital
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Takamura Toshinari
Department Of Diabetes And Digestive Disease Kanazawa University Graduate School Of Medical Science
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Kahara Toshio
Department Of Internal Medicine Kanazawa National Hospital
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Matsushita Eiki
Department Of Internal Medicine (i) School Of Medicine Kanazawa University
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Ishikura Kazuhide
Department Of Internal Medicine Toyama Prefectural Central Hospital
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Kahara Toshio
Department of Endocrinology and Metabolism (First Department of Internal Medicine), Kanazawa University Graduate School of Medical Science
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ISHIKURA Kazuhide
Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science
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