Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse
スポンサーリンク
概要
- 論文の詳細を見る
Objective: Myeloid-derived suppressor cells (MDSCs) have been identified as immunosuppressive cells in tumor-related inflammation. However, the pathogenesis of MDSCs for autoimmune disease has not been investigated as yet. The aim of this study was to address whether MDSCs contribute to autoimmune organ injury in lupus-prone mice. Methods: MDSCs were analyzed by flow cytometric staining of CD11b+ GR-1+ in MRL-Faslpr mice. CD4+ T-cell proliferation assay was performed by coculture with CD11b+ GR-1+ splenocytes. The percentage of immunosuppressive cells was examined during disease progression. Expression of chemokine receptor on immunosuppressive cells was analyzed, and chemotaxis assay was performed. Results: CD11b+ GR-1low cells had a suppressive effect on CD4+ T-cell proliferation, which was restored by an arginase-1 inhibitor. CD11b+ GR-1low cells increased in percentage during disease progression in kidney and blood. The number of migrated CD11b+ GR-1low cells increased in the presence of monocyte chemoattractant protein-1/CCL2. Conclusion: We assessed the involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mice. These cells regulate immunological responses via CCL2/CCR2 signaling. The regulation of immunosuppressive monocytes may provide novel therapeutic strategy for organ damage in autoimmune diseases. © 2010 Japanese Society of Nephrology..
- 2010-10-01
著者
-
Kaneko Shuichi
Department Of Disease Control And Homeostasis Kanazawa University Graduate School Of Medical Science
-
MATSUSHIMA Kouji
Department of Pharmacology, Institute of Cancer Research, Kanazawa University
-
WADA Takashi
Department of Gastroenterology and Nephrology, Kanazawa University Graduate School of Medical Scienc
-
Wada Takashi
金沢大学 医学部血液浄化療法部
-
Iwata Yasunori
Department of Internal Medicine, Toyama Prefectural Central Hospital
-
Shimizu Kazuaki
Department Of Gastroenterology And Nephrology Kanazawa University Graduate School Of Medicine
-
Furuichi K
金沢大学 医学系研究科恒常性制御学
-
Furuichi Kengo
Kanazawa Univ. Hospital Kanazawa Jpn
-
Kaneko Shuichi
Departments Of Gastroenterology Graduate School Of Medical Sciences Kanazawa University
-
Wada Takashi
Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn
-
Hara Akinori
Department Of Internal Medicine Tsuruga Municipal Hospital
-
Ueha Satoshi
Department Of Molecular Preventive Medicine And Sorst Graduate School Of Medicine University Of Toky
-
Ueha Satoshi
Department Of Molecular Preventive Medicine & Sorst Graduate School Of Medicine University Of To
-
Kokubo Satoshi
金沢大学 医学系研究科恒常性制御学
-
Iwata Yasunori
The Department Of Gastroenterology And Nephrology
-
Sakai Norihiko
Division Of Blood Purification Graduate School Of Medical Science Kanazawa University
-
Sakai Norihiko
The Department Of Gastroenterology And Nephrology
-
Sakai Norihiko
富山県立中央病院
-
Sakai Norihiko
Department Of Medicine Toyama Prefectural Central Hospital
-
Kaneko S
Departments Of Gastroenterology Graduate School Of Medical Sciences Kanazawa University
-
Kokubo Satoshi
The Department Of Gastroenterology And Nephrology
-
Kaneko Shuichi
Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn
-
Wada T
Division Of Blood Purification Department Of Gastroenterology And Nephrology Graduate School Of Medi
-
KITAGAWA Kiyoki
The Department of Gastroenterology and Nephrology
-
Matsushima Kouji
Department Of Allergy And Immunology National Research Institute For Child Health & Development
-
Matsushima Kouji
Department Of Molecular Preventive Medicine And Sorst Jst Graduate School Of Medicine The University
-
Wada Takashi
Department Of Dermatology Asahikawa Medical College
-
Kaneko Shuichi
Department Of Cancer Gene Regulation Kanazawa University
-
Kokubo Satoshi
Departments Of Gastroenterology Graduate School Of Medical Sciences Kanazawa University
-
Wada Takashi
Department Of Laboratory Medicine Kanazawa University Graduate School Of Medical Science
-
Wada T
Department Of Laboratory Medicine Graduate School Of Medical Science Kanazawa University
-
Iwata Yasunori
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
FURUICHI Kengo
Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Scien
-
KITAGAWA Kiyoki
Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Scien
-
OKUMURA Toshiya
Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Scien
-
SAGARA Akihiro
Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Scien
-
KUROKAWA Yukie
Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Scien
-
Sakai Norihiko
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Furuichi Kengo
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Kitagawa Kiyoki
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Okumura Toshiya
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Kurokawa Yukie
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Sagara Akihiro
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Kokubo Satoshi
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Hara Akinori
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Shimizu Kazuaki
Department Of Disease Control And Homeostasis Institute Of Medical Pharmaceutical And Health Science
-
Matsushima Satoshi
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Okayama University
-
Ueha Satoshi
Department Of Molecular Preventive Medicine University Of Tokyo
-
Kaneko Shuichi
Department Of Gastroenterology Kanazawa University Hospital
-
WADA Takashi
Department of Clinical Laboratory, Kanazawa University Hospital
関連論文
- Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A
- 緑膿菌由来のIL-8誘導蛋白の生物学的活性とその臨床的意義
- Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells
- Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study
- Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
- Case-control study for the identification of virological factors associated with fulminant hepatitis B
- Timing of interferon therapy and sources of infection in patients with acute hepatitis C
- Effect of sevelamer hydrochloride on markers of bone turnover in Japanese dialysis patients with low biointact PTH levels
- Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation followed by immunosuppression for acute lymphocytic leukemia
- The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis : A prospective, multicenter study
- Oral etoposide following combination chemotherapy and radiation therapy in a patient with advanced adult neuroblastoma led to long survival
- The committee for revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma
- Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease
- Apoptosis of murine cultured biliary epithelial cells induced by glycochenodeoxycholic acid involves Fas receptor and its ligand
- Treatment with chondroitinase ABC alleviates bleomycin-induced pulmonary fibrosis
- Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.
- Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy
- DPE-068 Muscle Atrophy F-box Inhibited Pressure Overload Induced Cardiac Hypertrophy through the Activation of NF κ-B Pathway(DPE12,Cardiomyopathy/Hypertrophy (Basic) (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- PJ-672 G_ and G_q Coordinately Mediate S1P_2-induced Inhibition of Rac and Migration in Vascular Smooth Muscle in Rho-dependent Manner(PJ113,Atherosclerosis, Basic 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
- PJ-373 Sphingosine-1-Phosphate Inhibits the Formation of Tube-Like Structures via Its Receptor EdgS in Vascular Endothelial Cells(Angiogenesis 3 (IHD) : PJ62)(Poster Session (Japanese))
- OE-012 Knockdown of Edg1 Gene Expression by RNA Interference Abolishes Sphingosine-1-Phosphate-Induced Platelet-Derived Growth Factor-B Chain Expression in Vascular Smooth Muscle Cells(Vasoactive Compound/Growth Factor/Cytokine 1 (H) : OE2)(Oral Presentat
- Current Status of Anticoagulation Therapy for Elderly Atrial Fibrillation Patients in Japan : From Hokuriku Atrial Fibrillation Trial
- PJ-232 Alterd Interaction between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity with Aging(Atherosclerosis,clinical(10)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-328 Present Educational System of Resuscitation dose not Encourage High School Students to fight Cardiopulmonary Arrest(Emergency care/CPR(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-146 Current Status of Anticoagulation Therapy for Elderly Patients, from Hokuriku Atrial Fibrillation Trial(Arrhythmia, therapy(12)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-124 Antioxidative Effect Provided with Statin Is Independent from LDL Lowering Mechanisms in the Clinical Course of Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of t
- PE-033 Altered Firing Pattern of Single-unit Sympathetic Vasoconstrictor Fibers during Exercise in Chronic Heart Failure(Autonomic nervous system(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-102 Sympathetic Augmentation was Induced by Strict Rate Control in AF Patient(Autonomic nervous system(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Altered Interaction Between Plasminogen Activator Inhibitor Type 1 Activity and Sympathetic Nerve Activity With Aging
- PJ-467 Interaction of Low Dose of Endotheline Blockade and Beta-adrenergic Receptor Antagonist Improved Coronary Flow Reserve after Ischemia Reperfusion Injury(Coronary circulation, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circ
- PJ-263 Additional Administration of Angiotensin Receptor Blockade with Aldosteron Antagonist Improved Oxidative Stress after Acute Coronary Syndrome in Human(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japa
- PJ-260 The Reduction of Cellular ER Stress Regarding with Chemical Chaperon Improves Myocardial Ischemia Reperfusion Injury in Mice(Myocardial ischemia/reperfusion, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-077 Atrial Fibrillation Itself Augments Single-unit Muscle Sympahtetic Nerve Activity in Congestive Heart Failure(Autonomic nervous system-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-203 Effect of Elevated Arterial Pressure on Vascular Functional and Structural Atherosclerosis in the Hypertensive Patients(Atherosclerosis, clinical-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-137 Azelnidipine Inhibits Single-unit Muscle Sympathetic Nerve Activity in Healthy Humans(Autonomic nervous system-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-576 Interaction of Endotheline Blockade and Beta-adrenergic Receptor Antagonist Improved Myocardial Apoptosis after Ischemia Reperfusion Injury in the Rat Heart(Acute coronary syndrome, basic/clinical-8 (IHD) PJ97,Poster Session (Japanese),The 70th Ann
- Evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules
- Pivotal role of CCL25 (TECK)-CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes
- Chemokine/chemokine receptor-mediated inflammation regulates pathologic changes from acute kidney injury to chronic kidney disease
- Human telomerase exists in two distinct active complexes in vivo
- B317 Evaluation of neem (Azadirachta indica A. Juss) against Leptocorisa chinensis
- Dual Pathways to Tubular Morphogenesis of Vascular Endothelial Cells by Human Glioma Cells : Vascular Endothelial Growth Factor/Basic Fibroblast Growth Factor and Interleukin-8
- Nodular malignant melanoma with Spitz nevus-like pathological features finally confirmed by the pathological feature of the sentinel lymph node
- RCAS1 antigen is highly expressed in extramammary Paget's disease and in advanced stage squamous cell carcinoma of the skin
- A Case of Bullous Pemphigoid with Antibodies against Intercellular 130KD Antigen
- Redistribution of selectin counter-ligandes induced by cytokines
- Emergence of the apple snail, Pomacea canaliculata (Gastropoda: Ampullariidae), after irrigation in a paddy
- Density-dependent growth and reproduction of the apple snail, Pomacea canaliculata:a density manipulation experiment in a paddy field
- Seasonal attraction of the rice bug, Leptocorisa chinensis Dallas (Heteroptera: Alydidae), to synthetic attractant
- Breakdown of Mucosal Immunity in Gut by 2,3,7,8-Tetraclorodibenzo-p-dioxin (TCDD)
- Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by Concanavalin A
- Measurement of Surface Patterns by Using Interference of Diffraeted Laser Beam
- The Rho/Rho-kinase Systems Are Involved in Rapid Pacing-induced Changes of Atrial Refractory Period in a Canine Model
- Quantiative Analysis of Oxidative Stress Directly Reflect the Clinical Course of Acute Coronary Syndrome(Acute Coronary Syndrome, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Interaction of Endotheline Blockade and Aldosterone Blockade Improved Myocardial Dysfunction After Ischemia Reperfusion Injury in the Rat Heart(Acute Myocardial Infarction, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Soci
- PJ-019 A New System for the Continuous Automated Measurement of the Carotid Arterial Wall Dynamics(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- PE-093 Influences of Pressor Stimuli on the Distensibility of Carotid Artery in Humans(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- PE-003 Rho-kinase Inhibitor Fasudil Prevents Atrial Electrical Remodeling in Atrial Fibrillation(Arrhythmia, Basic 2 (A) : PE1)(Poster Session (English))
- OJ-200 Effect of Aging on Low Frequency Components of Peripheral Vascular Resistance Variability in Human(Autonomic Nervous System 2 (H) : OJ23)(Oral Presentation (Japanese))
- Subacute Thyroiditis Developed in Identical Twins Two Years Apart
- Fibrocyte : New participant in the pathogenesis of renal fibrosis
- The role of fibrocytes in progressive renal fibrosis
- W1-3 Effect of Pollutants on Allergic Airway Responses : Studies with Diesel Exhaust Particles(DEP)in vitro and in vivo.
- Tiny staining spots in liver cirrhosis associated with HCV infection observed by computed tomographic hepatic arteriography: follow-up study
- IL-1 Induces Expression of p21^ Independently of p53 in High-Passage Human Embryonic Fibroblasts WI38
- Relationship between Plasma hANP Level and Pretibial Edema by Pioglitazone Treatment
- An open-label study of administration of EH0202, a health-food additive, to patients with chronic hepatitis C
- Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan
- Molecular functions and biological roles of hepatitis B virus x protein
- Maintenance of memory CD8^+ T cell diversity and proliferative potential by a primary response upon re-challenge
- Rejuvenation of T cell memory
- The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis
- 3-Methylcholanthrene-induced transforming growth factor-β-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy
- Type1 and type2 memory T cells imbalance shown by expression of intrahepatic chemokine receptors relates to pathogenesis of primary biliary cirrhosis
- Trans-basement membrane migration of human basophils : role of matrix metalloproteinase-9
- PE-002 Additional Administration of T-type Ca Antagonist Significantly Improved Oxidative Stress After Acute Coronary Syndrome in Human(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70th Anniversary Annual Scientific Mee
- Dacarbazine, Nimustine Hydrochloride, Cisplatin and Tamoxifen Combination Chemotherapy for Advanced Malignant Melanoma
- CD4^+CD25^+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype
- Molecular cloning, and characterization and expression of dihydrolipoamide acetyltransferase component of murine pyruvate dehydrogenase complex in bile duct cancer cells
- T_h -derived cytokine IFN-γ is a potent inhibitor of eotaxin synthesis in vitro
- Functional interaction of hepatitis C virus NS5B with nucleolin GAR domain
- Comprehensive gene expression profile of human activated T_h1-and T_h2-polarized cells
- The Participation of IL-8 in the Synovial Lesions at an Early Stage of Rheumatoid Arthritis
- A nationwide survey of rapidly progressive glomerulonephritis in Japan : etiology, prognosis and treatment diversity
- Design and methods of a strategic outcome study for chronic kidney disease : Frontier of Renal Outcome Modifications in Japan
- Chemokines and their receptors in cardiovascular diseases
- Migration of Dendritic Cells
- Prevention of endotoxin shock by an antibody against leukocyte integrin β_2 through inhibiting production and action of TNF
- Chemokines in the Bronchoalveolar Lavage Fluid of Patients with Sarcoidosis
- IL-10 augments the IFN-γ and TNF-α induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic dermatitis
- Monocyte chemotactic and activating factor (MCAF/MCP-1) has an autoinductive effect in monocytes, a process regulated by IL-10
- Selective recruitment of CCR4-bearing T^h2 cells toward antigen-presenting celsl by the CC chemokines thymus and activation-regulated chemokine and macropahe-derived chemokine
- The expression of chemokine receptor CXCR3 : relevance to disease activity of rheumatoid arthritis
- Induction of Interleukin 8 (IL-8) Production by Pseudomonas Nitrite Reductase in Human Alveolar Macrophages and Epithelial Cells
- Airway Interleukin-8 in Elderly Patients with Bacterial Lower Respiratory Tract Infections
- Intradermal transfer of caspase-1 (CASP1) DNA into mouse dissects : role of CASP1 in interleukin-1β associated skin inflammation and apoptotic cell death
- Increased spontaneous production of IL-8 in peripheral blood monocytes from the psoriatic patient : relation to focal infection and response to treatments
- Involvement of CD11b+ GR-1low cells in autoimmune disorder in MRL-Faslpr mouse
- A case of neurosarcoidosis with necrotizing granuloma expressing angiotensin-converting enzyme
- Benidipine reduces ischemia reperfusion-induced systemic oxidative stress through suppression of aldosterone production in mice