Rejuvenation of T cell memory

概要

論文の詳細を見る
Memory CD8+ T cells generated during an immune response are long-lived and self-renewing, off eringenhanced host protection against re-infection. However, how an antigen-specific population of memory T cells ismaintained throughout repetitive infections over potentially a lifetime is not known. Here we review the generationand maintenance of antigen-specifi c CD8+ T cells and introduce our recent data showing dynamic turnover of anantigen-specific memory T cell population during repeated antigen challenge in vivo. We demonstrated that aprimary response potentially occurs upon every recall response and fi nd that the skewed T-cell receptor （TCR）repertoire of pre-existing memory T cells is partly corrected by diversity in a newly formed （primary） population.Importantly, memory T cells generated in a more recent antigen encounter expand more vigorously in a subsequentrecall response. A primary response during re-challenge therefore restores both the TCR diversity and proliferativepotential of the memory T cell population. These findings indicate that memory T cell populations evolve overmultiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primarypopulations have essential roles in the perpetuation of antigen-specifi c T cell populations.
弘前大学の論文