IL-2 RECEPTOR GENE REGULATION BY CYTOKINES; ROLE OF ATL-DERIVED FACTOR(S)(ADFs) IN ATL

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概要

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• The humoral regulation of the IL-2 receptor (IL-2-R) gene expression was studied on the transcriptional as well as post-transcriptional levels. HTLV-I(+) leukemic T-cells and T-cell lines from the patients with Adult T-cell Leukemia (ATL) continuously expressed IL-2-R without production of IL-2. However, there was no abnormality of the structural gene for the IL-2-R in these cell lines as well as fresh leukemic cells of ATL. We have detected that many HTLV-I(+) T4(+) T-cell lines constitutively produce a non-IL-2 lymphokine named ATL-derived factor (ADF), which induced the expression of the high affinity IL-2-R on a variety of the cells including HTLV-I(+) T-cells as well as YT cells, a sensitive human NK cell line without rearrangement of T beta gene. IL-2-R on YT cells was also induced by a variety of IL-Is but not by IL-2, which effectively induced IL-2-R on T-cell lines. IL-2-R gene expression on YT cells is also induced by a variety of pharmacological agents including phorbol esters such as phorbol myristate acetate (PMA) and Forskolin, a direct activator of adenylate cyclase. In contrast to the preferential induction of the low affinity IL-2-R by PMA, Forskolin induced the high affinity IL-2-R on YT cells. These IL-2-R inducing agents such as ADF and Forskolin were shown to induce the elevation of the levels of mRNA for IL-2-R, through the enhancement of the transcription of the IL-2-R gene. The possible involvement of IL-2-R inducing cytokines in the physiological lymphocyte activation and the malignant transformation in ATL and other T-cell leukemias is discussed.

• 日本組織細胞化学会の論文

著者

• MAEDA Michiyuki

  Chest Disease Institute, Kyoto University

• Yodoi Junji

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Okada Masafumi

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Matsumoto Keizo

  Professor Emeritus Nagasaki Univ.

• Maeda Michiyuki

  Chest Disease Institute Kyoto University

• Matsumoto K

  Department Of Internal Medicine Institute Of Tropical Medicine Nagasaki University

• Hirata Masakazu

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Matsushima Kouji

  Department Of Allergy And Immunology National Research Institute For Child Health & Development

• Matsuno Kenjiro

  Department Of Anatomy (macro) & Sorst Dokkyo University School Of Medicine

• Matsushima Kouji

  Department Of Molecular Preventive Medicine & Sorst Graduate School Of Medicine University Of To

• UCHIYAMA Takashi

  First Division, Department of Internal Medicine

• Matsushima K

  Department Of Allergy And Immunology National Research Institute For Child Health & Development

• Matsushima Kouji

  First Department Of Internal Medicine Kyoto University Faculty Of Medicine

• TAGAYA YUTAKA

  Immunology Research Institute, Kyoto University Faculty of Medicine

• NAMBA TSUNEHISA

  Immunology Research Institute, Kyoto University Faculty of Medicine

• NARAMURA MAYUMI

  Immunology Research Institute, Kyoto University Faculty of Medicine

• Namba Tsunehisa

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Tagaya Yutaka

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Naramura Mayumi

  Immunology Research Institute Kyoto University Faculty Of Medicine

• Uchiyama Takashi

  First Department Of Internal Medicine Kyoto University Faculty Of Medicine

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