Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

概要

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Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 63-year-old man with bleeding tendency and a large palpable abdominal aortic aneurysm (AAA) was diagnosed as having fibrinolysis dominant DIC by the excessive activation of both coagulation and fibrinolysis (plasmin-α2 plasmin inhibitor complex concentration is usually >4μg/ml). Although several treatments were tried, DIC could not be controlled until the patient was given combined therapy of danaparoid (1,250U/12h, bolus IV) and tranexamic acid (0.5g×3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip.
社団法人日本循環器学会の論文
2005-08-20