Complete and durable remission of refractory mantle cell lymphoma with repeated rituximab monotherapy
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概要
- 論文の詳細を見る
We encountered a 53-year-old man with general fatigue. Bone marrow investigations revealed an infiltration of CD20+CD5 +CD23- cells and the presence of cyclin D1 lymphoid cells, leading to a diagnosis of mantle cell lymphoma, clinical stage IV. The first 2 lines of chemotherapy, CyclOBEAP (cyclophosphamide, vincristine, bleomycin, etoposide, doxorubicin, and prednisolone) and fludarabine-cyclophosphamide, produced only a transient decrease in serum lactic dehydrogenase levels, without a clinical remission. Because of the persistence of bone marrow hypoplasia, monotherapy with 375 mg/m2 rituximab was administered. The pancytopenia gradually improved, and a complete remission was obtained after 4 cycles of rituximab. The patient remains in complete remission 21 months after the third rituximab therapy for maintenance. ©2005 The Japanese Society of Hematology.
- 日本血液学会 = Japanese Society of Hematologyの論文
- 2005-05-15
著者
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OKUMURA Hirokazu
Department of Hematology, Kanazawa University Graduate School of Medical Science
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中尾 眞二
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
日本医科大学 第三内科
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NAKAO Shinji
Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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高見 昭良
金沢大学大学院医学系研究科細胞移植学
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TAKAMI Akiyoshi
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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KAMI Masahiro
Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital
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Ishiyama Ken
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Ishiyama Ken
金沢大学 細胞移植
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OKUMURA Hirokazu
Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Okumura Hirokazu
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Okumura Hirokazu
日本医科大学 第三内科
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Ozaki Jun
Ntt West Japan Kanazawa Hospital Kanazawa Jpn
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Nakao Shinji
Department Of Hematology Kanazawa University Graduate School Of Medical Science
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Takami Akiyoshi
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
Cellular Transplantation Biology Department Of Respiratory Medicine Kanazawa University Graduate Sch
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OZAKI Jun
Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School o
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SHIMADOI Shigeru
Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School o
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YAMANAKA Shin-ichi
Cellular Transplantation Biology, Division of Cancer Medicine, Kanazawa University Graduate School o
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Nakao Shinji
Third Department Of Internal Medicine Kanazawa University Medical School
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Yamanaka Shinichi
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Scienc
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Okumura Hirokazu
Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn
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Shimadoi Shigeru
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Scienc
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