Cord blood transplantation using minimum conditioning regimens for patients with hematologic malignancies complicated by severe infections
スポンサーリンク
概要
- 論文の詳細を見る
Patients with severe infections are thought to be ineligible for cord blood stem cell transplantation (CBT) because the conventional 5-6 day-conditioning regimens potentially makes them susceptible to fatal infections by the time neutrophil engraftment occurs. Two patients were treated with minimum conditioning regimens consisting of 30 mg/m2 fludarabin (Flu) and 2 g/m2 cyclophosphamide (CY) on day-1 and total body irradiation (TBI) of 2 or 4 Gy on day -1 or 0 followed by single unit CBT. The reasons for adopting such weak regimen were febrile neutropenia due to the rejection of the first cord blood (CB) graft given to a patient with follicular lymphoma resistant to chemotherapy and pulmonary aspergillosis in another patient with AML who relapsed after CBT. The AML patient received 40 mg/m2 of melphalan on day-2 to reduce the leukemia burden. Both patients achieved 100% donor chimerism by day 19 and day 20 after CBT without an apparent exacerbation of the infections and remained in remission at 23 and 18 months after the CBT. These findings suggest that the 1-2 day regimens excluding antihuman thymocyte globulin may be sufficiently potent to ensure engraftment of CB in immunocompromised patients and safely administered even when patients are complicated by active infections. © 2008 The Japanese Society of Hematology.
- 2009-03-15
著者
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OKUMURA Hirokazu
Department of Hematology, Kanazawa University Graduate School of Medical Science
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中尾 眞二
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
日本医科大学 第三内科
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NAKAO Shinji
Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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高見 昭良
金沢大学大学院医学系研究科細胞移植学
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TAKAMI Akiyoshi
Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine
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KAMI Masahiro
Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital
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Ishiyama Ken
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Ishiyama Ken
金沢大学 細胞移植
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Yasui Masahide
金沢大学 医学系研究科細胞移植学
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Yasui M
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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Sugimori Chiharu
金沢大学 医学系研究科細胞移植学
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Sugimori Chiharu
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Sugimori Chiharu
Department Of Cellular Transplantation Biology Kanazawa University Graduate School Of Medicine
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OKUMURA Hirokazu
Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Takaue Yoichi
国立がんセンター中央病院 造血幹細胞移植グループ
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Takaue Yoichi
Department Of Internal Medicine Ntt West Kanazawa Hospital
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Okumura Hirokazu
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Okumura Hirokazu
日本医科大学 第三内科
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Okumura H
Kanazawa Univ. Graduate School Of Medical Sci. Jpn
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NAKAO Shinji
Kanazawa University Hospital
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Yasui Masahide
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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Nakao Shinji
Department Of Hematology Kanazawa University Graduate School Of Medical Science
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Nakao Shinji
The Third Department Of Internal Medicine Kanazawa University School Of Medicine
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KONDO Yukio
Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Takami Akiyoshi
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Yoshida Tomotaka
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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YAMASHITA Takeshi
Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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YAMAZAKI Hirohito
Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science
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Nakao Shinji
Cellular Transplantation Biology Department Of Respiratory Medicine Kanazawa University Graduate Sch
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Kadohira Yasuko
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Yamashita Takeshi
Department Of Internal Medicine Ntt West Kanazawa Hospital
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Okumura Hirokazu
Kanazawa Univ. Graduate School Of Medical Sci. Kanazawa Jpn
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Kondo Yukio
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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Shirafuji Naoki
Department Of Hematology/oncology Teikyo University School Of Medicine
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Sahara Naohi
Department Of Internal Medicine Iii Hamamatsu University School Of Medicine
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Yamauchi H
Cellular Transplantation Biology Kanazawa University Graduate School Of Medical Science
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