Community-acquired Chlamydia pneumoniae Pneumonia in Japan : A Prospective Multicenter Community-acquired Pneumonia Study

元データ 2002-11-01 社団法人 日本内科学会

概要

Objective To investigate the clinical features of Chlamydia pneumoniae pneumoniae in Japan and to evaluate the newly created Japanese community-acquired pneumonia (CAP) guidelines. Patients and Methods A multicenter CAP surveillance study was carried out in 20 hospitals between December 1999 and March 2000. The diagnosis of C. pneumoniae infection was based on isolation in cell culture, the polymerase chain reaction and serologic testing of antibodies by the microimmunofluorescence test. Results Among 232 CAP cases, C. pneumoniae was identified as the etiologic agent in 15 cases (6.5 %). C. pneumoniae was the only pathogen identified in nine of these cases, while one or more additional etiological agents were found in the other six cases. Of the present and previously reported single agent C. pneumoniae pneumonia cases, about 50% were more than 60 years old and had underlying diseases. A relatively slow pulse rate in relation to fever was not seen in these patients. The mean WBC count of all patients was normal. No patient required respiratory support or admission to an intensive care unit and no deaths occurred among these patients. Conclusion The clinical pictures of C. pneumoniae pneumonia as a single agent were mild to moderate and were remarkably different from those of cases of C. pneumoniae pneumonia concomitant with other bacteria. If the patient is less than 60 years old and some guideline headings are excluded, we think it would be possible to distinguish between C. pneumoniae and bacterial pneumonia.(Internal Medicine 41: 943-949, 2002)

著者

YAMAGUCHI Keizo Department of Microbiology, Toho University School of Medicine
Matsushima Toshiharu 昭和大学 医学部臨床感染症学
Matsushima Toshiharu 東北大学加齢医学研究所 抗感染症薬開発研究部門
Kohno Shigeru the Second Department of Internal Medicine, Nagasaki University, School of Medicine
Niki Yoshihito 昭和大学 医学部臨床感染症学
Niki Y Showa University School Of Medicine Department Of Clinical Infectious Diseases
Yoshihito Niki Department Of Respiratory And Internal Medicine Kawasaki Medical School
Kawakami Shigeru 京都大学 薬学研究科
Kobashi Yoshihiro 川崎医科大学 医学部内科学(呼吸)
Sugahara Yazuyuki 長崎大学 医歯薬学総合研究科臨床検査医学講座
Niki Yoshihito Showa University School Of Medicine Department Of Clinical Infectious Diseases
Kubota Y Division Of Respiratory Diseases Department Of Medicine Kawasaki Medical School
Yoshida Kouichirou 昭和大学 医学部臨床感染症学
Watanabe Akira Department of Biological Sciences, Graduate School of Science, University of Tokyo
Sugahara Yazuyuki Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
SAITO Atsushi First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
SAITO Atsushi the First Department of Internal Medicine, Faculty of Medicine, University of Ryukyus
Manabe Takao 大阪市立総合医療センター
Matsushima T Division Of Respiratory Diseases Department Of Medicine Kurashiki Daiichi Hospital
Matsushima Toshiharu The Division Of Respiratory Diseases Department Of Medicine Kawasaki Medical School.
Saito Atsushi The First Department Of Internal Medicine Faculty Of Medicine University Of The Ryukyus
Oda Hiroshi Department Of Orthopaedic Surgery Nihon University School Of Medicine
Yamaguchi Keizo Department Of Microbiology Toho University School Of Medicine
MATSUSHIMA Toshiharu Junpukai Kurashiki Daiichi Hospital
OIZUMI Kotaro Department of Internal Medicine, Kurume University
MIYASHITA Naoyuki the Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
OIZUMI Kotaro the First Department of Internal Medicine, Kurume University School of Medicine
FUKANO Hiroshi the Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
YOSHIDA Koichiro the Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
NIKI Yoshihito the Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
Oda Hiroshi Department Of Bacteriology Faculty Of Medicine Kagoshima University
Oizumi Kotaro The First Department Of Internal Medicine Kurume University
Yamaguchi Keizo Department Of Infectious Diseases Toho University School Of Medicine
Matsushima Toshiharu The Division Of Respiratory Diseases Department Of Medicine
Matsushima Toshiharu The Division Of Respiratory Diseases Department Of Medicine Kawasaki Medical School
Takashima M Japan Collection Of Microorganisms Riken (the Institute Of Physical And Chemical Research)
Yoshida Koichiro Department Of Clinical Infectious Diseases School Of Medicine Showa University
Kohno Shigeru The Second Department Of Internal Medicine Nagasaki University
Manabe T Osaka City General Hospital
Miyashita Naoyuki Department Of Respiratory Diseases Kawasaki Medical School
Watanabe Akira Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
Miyashita Naoyuki Department Of Respiratory Medicine Kawasaki Medical School
Kohno Shigeru The Scientific Assembly For Infection And Tuberculosis Of The Japanese Respiratory Society
Matsushima Toshiharu The Department Of Internal Medicine Division Of Respiratory Diseases Kawasaki Medical School
Saito Atsushi The First Department Of Internal Medicine Faculty Of Medicine University Of Ryukyus
Kobashi Yoshihiro The Division Of Respiratory Diseases Department Of Medicine Kawasaki Medical School Kawasaki Hospita
Watanabe Akira Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
Saito Atsushi First Department Of Internal Medicine University Of The Ryukyus School Of Medicine
Fukano Hiroshi Department Of Internal Medicine Center For Respiratory Disease Kurashiki Daiichi Hospital
Yamaguchi Keizo Department Of Clinical Laboratory Nagasaki University Hospital
Yoshida Kouichirou Division Of The Respiratory Diseases The Department Of Medicine Kawasaki Medical School

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