Role of Autonomic Nervous Dysfunction in Electrocardio-graphic Abnormalities and Cardiac Injury in Patients With Acute Subarachnoid Hemorrhage
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概要
- 論文の詳細を見る
Electrocardiographic abnormalities, cardiac injury, and autonomic nervous function were investigated in patients with acute-phase subarachnoid hemorrhage (SAH) (42 patients with SAH related to ruptured aneurysm and 42 control subjects). Electrocardiogram and Holter electrocardiogram for spectral analysis of heart rate variability (HRV) were recorded. Concentrations of cardiogenic enzymes (ie, creatine kinase-myocardial fraction [CK- MB], myosin light chain I, and troponin T), plasma concentrations of catecholamine (ie, noradrenaline, adrenaline, 3-methoxy-4-hydroxy-phenylethylene glycol [MHPG]) and HRV were compared in the acute and chronic phase of SAH, and with the values in the controls subjects. As previously reported, patients with acute SAH exhibited electrocardiographic (ECG) abnormalities and increased concentrations of both cardiogenic enzymes and plasma catecholamines, suggesting that acceleration of sympathetic activity is involved. However, HRV analysis showed enhanced parasympathetic activity, probably associated with increased intracranial pressure after the onset of SAH, which may be explained by accentuated antagonism, negative feedback of noradrenaline to the center, and reduction of sympathetic activity after reaching a peak level. The results suggest that not only sympathetic activity but also vagal activity is enhanced during the acute phase of SAH, thus contributing to the ECG abnormalities and the onset of cardiac injury. (Circ J 2003; 67: 753-756)
- 社団法人日本循環器学会の論文
- 2003-08-20
著者
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Kawabata S
Second Dep. Of Internal Medicine Nagasaki Univ. School Of Medicine
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Miyahara Yoshiyuki
the Second Department of Internal Medicine, Nagasaki University, School of Medicine
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Ikeda Satoshi
the Second Department of Internal Medicine, Nagasaki University, School of Medicine
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Kohno Shigeru
the Second Department of Internal Medicine, Nagasaki University, School of Medicine
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Shimokawa Isao
Nagasaki Univ. Nagasaki Jpn
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Miyazaki Y
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Kohno Shigeru
長崎大学医学部歯学部附属病院 薬剤部
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Sugahara Yazuyuki
長崎大学 医歯薬学総合研究科臨床検査医学講座
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Kohno Shigeru
長崎大学 第二内科
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Ikeda Satoshi
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
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Sakanaka Koji
参天製薬奈良研究開発センター
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Miyahara Yoshiyuki
2nd Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Science
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Maeda Yasuhiro
Department Of Hematology Kinki University School Of Medicine
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Ikeda Satoshi
Department Of Cardiovascular Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Kawahara Eisuke
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Miyahara Yoshiyuki
Second Department Of Internal Medicine Nagasaki University School Of Mediciene
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Miyahara Yoshiyuki
The Second Department Of Internal Medicine Nagasaki University
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Kohno Shigeru
The Second Department Of Internal Medicine Nagasaki University
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Miyazaki Yasushi
Department Of Hematology Kinki University School Of Medicine
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Kawahara Eisuke
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Kohno Shigeru
The Scientific Assembly For Infection And Tuberculosis Of The Japanese Respiratory Society
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Ikeda Satoshi
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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