Response to Urinary Trypsin Inhibitor Therapy in Ulcerative Colitis is Associated With a Decrease in Mast Cell Count in the Colonic Mucosa
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概要
- 論文の詳細を見る
BACKGROUND: Urinary trypsin inhibitor (UTI, ulinastatin (R)) inhibits proteinases and has been used for the treatment of ulcerative colitis (UC). We investigated the therapeutic effect of UTI in patients with UC and correlated this effect to mast cell (MC) and macrophages (M) counts in the colonic mucosal wall. DESIGN: Patients with UC resistant to corticosteroids (n=16) and normal control subjects (n=10) were included in this study. Biopsy specimens obtained from the sigmoid colon of patients before and after UTI therapy were immunostained with antibodies to tryptase (AA1, MC) and CD68 (M). The number of MC and M in the lamina propria (LP) was determined and expressed per mm2 of LP. RESULTS: Nine patients with UC responded to UTI treatment. The mean number of MC in the upper part of LP in responders(440ﾂｱ51/mm2)was higher than nonresponders (312ﾂｱ76/mm2)and normal controls(200ﾂｱ47/mm2). MC counts in the lower part of the LP were not different in responders and nonresponders, although the counts in both groups were significantly higher than control. The number of M in the lower part of LP was similar in responders and nonresponders, but were higher than control subjects. M counts in the upper part of LP were similar in both groups of patients and control. Effective treatment with UTI in responders was associated with a significant fall in the number of MC in the upper layer of LP but not in M. CONCLUSION. Our results showed that UTI is an effective therapy in steroid-resistant UC. Our results also showed effective therapy with UTI was associated with a reduction in MC counts in the colonic mucosa, suggesting that the control of these cells may mediate, at least in part, the therapeutic effects of UTI in UC.
- 長崎大学の論文
著者
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Kawabata S
Second Dep. Of Internal Medicine Nagasaki Univ. School Of Medicine
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Takeshima Fuminao
Department of General Medicine, Nagasaki University School of Medicine
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Murase Kunihiko
Second Department of Internal Medicine, Nagasaki University School of Medicine
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Isomoto Hajime
佐世保市立総合病院
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Isomoto Hajime
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyazaki Y
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Kohno Shigeru
佐世保市立総合病院 内科
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Isomoto Hajime
長崎大学 第二内科
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Kanazawa Shigeo
Department Of Surgery Mitsugi Municipal General Hospital
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Onita Ken
長崎大学 第二内科
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Murase Kunihiko
Department of Surgery, Mitsugi General Hospital
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Murase K
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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FURUSU Hisashi
Second Department of Internal Medicine, Nagasaki University School of Medicine
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Nishida Yoshiyuki
Second Department of Internal Medicine, Nagasaki University School of Medicine
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Furusu Hisashi
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyahara Yoshiyuki
2nd Department Of Internal Medicine Nagasaki University School Of Medicine
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Takeshima Fuminao
Department Of General Medicine Nagasaki University School Of Medicine
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Nishida Yoshiyuki
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Kanazawa Shigeo
Department Of Surgery Ishikawa General Hospital
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Omagari Katsuhisa
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Otsuka Kikuo
Department Of Gastroenterology And Hepatology Nagasaki University Graduate School Of Biomedical Scie
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Kohno Shigeru
The Jikei University School Of Medicine
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