Renoprotective Effect of Azelnidipine in Rats

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概要

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• To assess whether azelnidipine (AZN) exerts renoprotective effects, 20-week-old adult male stroke-prone spontaneously hypertensive rats (SHRsp) were treated with AZN 10 mg/kg/d (n=6), olmesartan (OLM) 3 mg/kg/d (n=4), hydralazine (HYD) 20 mg/kg/d (n=3), or water (control; n=5). Each test agent was administered by oral gavage for 12 weeks. Systolic blood pressure (SBP) was measured every 2 weeks and urinary protein excretion (UproV) every 3 weeks. At the age of 32 weeks, the rats were sacrificed and blood and kidneys collected for biochemical, histological, and immunohistochemical studies. All drug treatments significantly (p<0.05) reduced SBP, UproV, and blood biochemical parameters such as creatinine, total cholesterol, and blood urea nitrogen. Masson trichrome staining and immunohistochemical staining revealed significant (p<0.05) reductions of interstitial fibrosis, collagen type III, nicotinamide-adenine dinucleotide/nicotinamide-adenine dinucleotide phosphate oxidase, and p22phox and p47phox components expression in the AZN- and OLM-treated groups in comparison with rats treated with HYD and control animals. ED1, 4-hydroxy-2-nonenal (4-HNE), and heat shock protein (HSP)-47 expression was also reduced in the AZN- and OLM-treated groups versus in HYD and control animals. These results indicate that not only OLM but also AZN exerts renoprotective effects through inhibition of macrophage infiltration and antioxidant activity in SHRsp model of renal injury.

• 社団法人日本薬学会の論文
• 2008-12-01

著者

• 上平 憲

  長崎大学医学部附属病院検査部

• Kawabata S

  Second Dep. Of Internal Medicine Nagasaki Univ. School Of Medicine

• Kohno Shigeru

  長崎大学 医学部第二内科

• Kohno S

  Second Dep. Of Internal Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ

• Kohno Shigeru

  佐世保市立総合病院

• Kohno Shigeru

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Kamihira Shimeru

  長崎大学 医歯薬学総合研究科臨床検査医学講座

• 上平 憲

  長崎大学臨床検査医学

• Sugahara Kazuyuki

  Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital

• Sugahara Kazuyuki

  長崎大学 医歯薬学総合研究科臨床検査医学講座

• 小路 武彦

  長崎大学第三解剖

• Kawakami S

  Santen Pharmaceutical Co. Ltd. Nara Research And Development Center:department Of Hospital Pharmacy

• Kawakami Shigeru

  京都大学 薬学研究科

• Kawakami Shigeru

  Dep. Of Drug Delivery Res. Graduate School Of Pharmaceutical Sciences Kyoto Univ.

• Harada Takashi

  Division Of Nephrology Clinical Research Center National Kyushu Medical Center

• Koji Takehiko

  長崎大学 医歯薬学総合研究科第2内科

• Koji Takehiko

  Department Of Histology And Cell Biology Nagasaki University Graduate School Of Biomedical Sciences

• Otsu Yoshiko

  長崎大学 医歯薬総研内科学第2

• Kohno Shigeru

  The Second Department Of Internal Medicine Nagasaki University School Of Medicine

• Kohno Shigeru

  長崎大学医学部歯学部附属病院 薬剤部

• Kohno Shigeru

  Nagasaki University

• 小路 武彦

  長崎大学 医学部 第三解剖

• 小路 武彦

  長崎大・医・第三解剖

• Kawakami S

  Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Sugahara Yazuyuki

  長崎大学 医歯薬学総合研究科臨床検査医学講座

• MIYAZAKI Masanobu

  Second Department of Internal Medicine, Nagasaki University

• Kohno Shigeru

  長崎大学 第二内科

• Kohno Shigeru

  東北大学加齢医学研究所 抗感染症薬開発研究部門

• Kanazawa Shigeo

  公立みつぎ総合病院

• Furusu Akira

  長崎大学 医学部第二内科

• Furusu Akira

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Furusu Akira

  長崎大学 医学部内科学第2

• Kawabata S

  Santen Pharmaceutical Co. Ltd. Nara Research And Development Center:department Of Hospital Pharmacy

• Nakazawa Yuka

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Sakanaka Koji

  参天製薬奈良研究開発センター

• 小路 武彦

  長崎大学大学院医歯薬学総合研究科組織細胞生物学分野

• 小路 武彦

  長崎大学医学部発生分化再生医学講座形態制御動態解析学領域

• 小路 武彦

  長崎大学医学部解剖学第三講座

• KURASHIGE Tomomi

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• ABE Katsushige

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• OBATA Yoko

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• XIA Zihyin

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• NAKAZAWA Masayuki

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• FUNAKOSHI Satoshi

  Sakuramachi Clinic

• Miyazaki Masanobu

  Miyazaki clinic

• Obata Yoko

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Koji Takehiko

  Division Of Histology And Cell Biology Department Of Developmental And Reconstructive Medicine

• Kobayashi Toshimitsu

  Dept. Of Otolaryngology

• Kurosawa Takako

  Department Of Obstetrics And Gynecology University Of Tokyo

• Kimura T

  Department Of Bacteriology Institute Of Tropical Medicine Nagasaki University

• Kohno Shigeru

  Second Department Of Internal Medicine Nagasaki University School Of Mediciene

• 上平 憲

  長崎大学医学部臨床検査医学

• Kashiwagi Satsuki

  School Of Pharmaceutical Sciences Nagasaki University

• Koji Takehiko

  Department Fo Histology And Cell Biology Nagasaki University School Of Medicine

• Koji Takehiko

  Department Of Histology And Cell Biology Nagasaki University School Of Medicine.

• Harada Takashi

  Division Of Renal Care Unit Nagasaki University School Of Medicine

• Xia Zihyin

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Kohno Shigeru

  Second Dep. Of Internal Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ

• Koji T

  Department Of Histology And Cell Biology Nagasaki University Graduate School Of Biomedical Sciences

• Abe Katsushige

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Miura Masahiko

  Department Of Internal Medicine School Of Medicine Tokai University

• Sakanaka Koji

  Department Of Hospital Pharmacy Nagasaki University Hospital Of Medicine And Dentistry:santen Pharma

• Kouno Sigeru

  Second Department Of Internal Medicine Nagasaki University School Of Mediciene

• Nakazawa Masayuki

  Second Depertment Of Internal Medicine Nagasaki University School Of Medicine

• Kurashige Tomomi

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• Harada T

  Nec Corp. Kawasaki‐shi Jpn

• Abe Kaoru

  Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences

• 小路 武彦

  Department Of Obstetrics And Gynecology The University Of Tokyo

• MIYAZAKI Masanobu

  Second Department of Internal Medicine Nagasaki University Graduate School of Biosciences

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