Elevated Levels of Tenascin-C in Patients with Cryptogenic Organizing Pneumonia
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概要
- 論文の詳細を見る
Objective Idiopathic interstitial pneumonias (IIPs) comprises a group of diffuse parenchymal lung diseases of unknown etiology with varying degrees of inflammation and fibrosis including cryptogenic organizing pneumonia (COP), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP). Tenascin-C is an extracellular matrix molecule that is expressed during wound healing in various tissues. The present study was aimed to investigate the role of tenascin-C in the pathogenesis of IIPs. Methods We used enzyme-linked immunosorbent assays to measure levels of tenascin-C in serum and bronchoalveolar lavage fluid (BALF) from 17 patients with IPF, 12 with NSIP, 15 with COP and from 23 healthy individuals. Results Serum levels of tenascin-C were significantly elevated in patients with COP compared with those in all other participants, whereas those in patients with IPF and NSIP were not significantly elevated compared with healthy individuals. The levels of tenascin-C in BALF from patients with COP and NSIP were significantly higher than those of healthy individuals. In addition, serum tenascin-C was significantly correlated with levels of serum C-reactive protein, which is a serum acute phase protein. Conclusion Systemic inflammation in the lung with IIPs might be associated with tenascin-C. These results suggest that tenascin-C is responsible for the pathogenesis of IIPs especially via inflammation, and that it might serve as a serum marker of COP.
- 日本内科学会,The Japanese Society of Internal Medicineの論文
著者
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Kohno Shigeru
the Second Department of Internal Medicine, Nagasaki University, School of Medicine
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HAYASHI Tomayoshi
Department of Pathology, Nagasaki University Hospital of Medicine and Dentistry
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ISHII Hiroshi
Department of Gastroenterology, Cancer Institute Ariake Hospital
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Sakamoto Noriho
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Ishimatsu Yuji
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Nakayama Seiko
Dep. Of General Medicine Nagasaki Univ. School Of Medicine
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Nakayama Seiko
Department Of Pathology Nagoya University School Of Medicine
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Hisatomi Keiko
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Mukae Hiroshi
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Amenomori Misato
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Ishimoto Hiroshi
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Fujita Hanako
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Mukae Hiroshi
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Hayashi Tomayoshi
Department Of Cardiovascular Surgery And Pathology Nagasaki University School Of Medicine
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Kohno Shigeru
The Scientific Assembly For Infection And Tuberculosis Of The Japanese Respiratory Society
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Ishii Hiroshi
Department Of Chemical Science And Engineering Tokyo National College Of Technology
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Nakayama Seiko
Department of General Medicine, Nagasaki University Hospital
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