BRAIN DISTRIBUTION OF HYDRAZINE AND ITS GABA ELEVATING EFFECT IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
After the intravenous administration of isoniazid (INH ; 0.37mmol/kg) or hydrazine (Hz ; 0.16mmol/kg), the minor metabolite of INH, γ-aminobutyric acid (GABA) and Hz were measured by means of gas chromatograph-mass spectrometer (GC-MS) using deuterium labeled GABA (d_2-GABA) and nitrogen fifteen labeled Hz (^15N-Hz) as internal standards. In both cases, we successfully detected Hz and GABA in the brain. The brain GABA elevating effect of Hz was much higher than that of INH in spite of low dose.
- 公益社団法人日本薬学会の論文
著者
-
Sendoh Toshiaki
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
-
NODA Atsuko
Faculty of Pharmaceutical Sciences, Kyushu University
-
SENDO TOSHIAKI
Faculty of Pharmaceutical Sciences, Kyushu University, School of Medicine, Kyushu University
-
MATSUYAMA KENJI
Faculty of Pharmaceutical Sciences, Kyushu University
-
IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
-
YAMASHITA CHIKAMASA
Faculty of Pharmaceutical Sciences, Kyushu University
-
SUGIYAMA KAZUSHI
Faculty of Pharmaceutical Sciences, Kyushu University
-
Matsuyama Kenji
Faculty Of Pharmaceutical Sciences Kyushu University
-
Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
-
Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
-
Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
-
Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University
-
Noda H
Faculty Of Pharmaceutical Sciences Kyushu University
-
Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
-
Iguchi Sadao
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
-
Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
-
Noda A
Faculty Of Pharmaceutical Sciences Kyushu University
-
Sendo Toshiaki
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
-
Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
-
Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
-
Sugiyama Kazushi
Faculty Of Pharmaceutical Sciences Kyushu University
関連論文
- The Bitterness Intensity of Clarithromycin Evaluated by a Taste Sensor
- Effect of Quinine Solutions on Intracellular Ca^Levels in Neuro-2a Cells : Conventional Physiological Method for the Evaluation of Bitterness(Miscellaneous)
- Consideration on Prevention of Phlebitis and Venous Pain from Intravenous Prostaglandin E_1 Administration by Adjusting Solution pH : In Vitro Manipulations Affecting pH
- β-Adrenoceptor Antagonistic Actions and Mutagenicities of R(+)- and S(-)-Enantiomers of N-Desisopropylpropranolol and Its N-Acetyl Conjugate
- MOLECULAR MECHANISM OF ISONIAZID INDUCED HEPATITIS. ROLE OF ACTIVE METABOLITES OF HYDRAZINE
- ENHANCED HEPATITIS OF ISONIAZID INDUCED BY RIFAMPICIN COADMINISTRATION. ROLE OF THE ISONIAZID METABOLITE, HYDRAZINE
- FURTHER INVESTIGATIONS ON BRAIN DISTRIBUTION OF HYDRA ZINE AND ITS γ-AMINOBUTYRIC ACID ELEVATING EFFECT IN RATS
- BRAIN DISTRIBUTION OF HYDRAZINE AND ITS GABA ELEVATING EFFECT IN RATS
- The Effect of Various Substances on the Suppression of the Bitterness of Quinine-Human Gustatory Sensation, Binding, and Taste Sensor Studies
- A New Method for Evaluating the Bitterness of Medicines by Semi-continuous Measurement of Adsorption Using a Taste Sensor
- Preparation and Characterization of Insulin-Loaded Acrylic Hydrogels Containing Absorption Enhancers
- Quantitative Evaluation of the Bitterness of Commercial Medicines Using a Taste Sensor
- Preparation and Characterization of Acrylic Hydrogels Neutralized by Basic Amino Acids
- SYNTHESIS OF VALPROYL-2-PYRROLIDINONE AND ITS EVALUATION AS A COGNITIVE DRUG WITH THE ABILITY TO MODULATE ACIDIC AMINO ACIDS IN THE BRAIN
- Determination of γ-Aminobutyric Acid and Associated Amino Acids in Mouse Brain by Liquid Chromatography
- Zero-Order Release from Cylindrical Xerogel Preparation
- PREPARATION AND BIOPHARMACEUTICAL EVALUATION OF MICROCAPSULES : AMOXICILLIN AND PIRETANIDE
- Chiral separation of 10,11-dihydro-10,11-trans-dihydroxycarbamazepine, a metabolite of carbamazepine with two asymmetric carbons, in human serum
- Determination of isonicotinic acid in the presence of isoniazid and acetylisoniazid Studies on isonicotinic acid formation from isoniazid in isolated rat hepatocytes
- Preparation and Characterization of Polylactic Acid Microspheres Containing Water-Soluble Anesthetics with Small Molecular Weight
- PRODUCT INHIBITION OF AMINOPYRINE N-DEMETHYLATION IN ISOLATED HEPATOCYTES
- EFFECT OF ENVIRONMENTAL TEMPERATURE ON THE CONTENT OF CYTOCHROME P-450 AND ACTIVITY OF NADPH-CYTOCHROME C REDUCTASE IN RATS
- INFLUENCE OF PHENOBARBITAL AND 3-METHYLCHOLANTHRENE ON THE METABOLISM OF AMINOPYRINE IN ISOLATED HEPATOCYTE SYSTEM
- TISSUE DISTRIBUTION OF ISONIAZID AND ITS METABOLITES IN RATS
- STUDIES ON THE MECHANISM OF HYDRAZINES FORMATION FROM ISONIAZID AND THEIR DISTRIBUTION IN THE MAIN ORGANS
- METABOLISM OF ISONIAZID AND FREE HYDRAZINE FORMATION IN ISOLATED RAT HEPATOCYTES
- Further Metabolism of 4-Acetylaminoantipyrine, the Major Metabolite of Aminopyrine, in Rats(Pharmacological)
- BIOHYDROXYLATION OF AMINOPYRINE : QUANTITATIVE STUDIES OF 3-HYDROXYMETHYL METABOLITE IN RATS
- An Attempt to Evaluate the Effect of Vitamin K_3 Using as an Enhancer of Anticancer Agents(Pharmacology)
- TISSUE DISTRIBUTION OF HYDRAZINE AND ITS METABOLITES IN RATS
- Preparation and Characterization of Polylactic Acid Microspheres Containing Bovine Insulin by a w/o/w Emulsion Solvent Evaporation Method
- Effect of Cholestyramine on the Pharmacokinetics and Pharmacodynamics of Bezafibrate in Rats
- ENHANCED MYOPATHY FOLLOWING ADMINISTRATION OF HYPOLIPIDEMIC AGENTS UNDER URETHANE ANESTHESIA
- Drug Interaction between Simvastatin and Cholestyramine in Vitro and in Vivo
- Enantioselective N-Acetylation of N-Desisopropylpropranolol by Rat Liver Acetyltransferase
- Participation of P450-Dependent Oxidation of Isoniazid in Isonicotinic Acid Formation in Rat Liver
- FATE OF DRUGS IN MAN UNDER GASTRIC CONDITIONS-WITH SPECIAL REFERENCE TO HYDRALAZINE
- CHARACTERISTIC BIOTRANSFORMATION OF AMINOPYRINE IN RAT WHEN ADMINISTERED WITH BARBITAL
- HYDRAZINE FORMATION FROM IPRONIAZID
- SALIVARY CONCENTRATION OF AMINOPYRINE AND ITS METABOLITES IN MAN
- QUANTITATIVE DETERMINATION OF HYDRAZINES DERIVED FROM ISONIAZID IN PATIENTS. I
- Preparation and Characterization of Enteric Microspheres Containing Bovine Insulin by a w/o/w Emulsion Solvent Evaporation Method