Further Metabolism of 4-Acetylaminoantipyrine, the Major Metabolite of Aminopyrine, in Rats(Pharmacological)
スポンサーリンク
概要
- 論文の詳細を見る
A significant reduction of urinary excretion of 4-acetylaminoantipyrine (AcAA) after administration of aminopyrine was observed in rats treated with phenobarbital or with 3-methylcholanthrene. Urinary excretion data and results obtained in the isolated rat hepatocyte system clearly demonstrated that both an alternative route of metabolism of 4-aminoantipyrine, an AcAA precursor, and further metabolism of AcAA itself accounted for the considerable reduction of AcAA recovery. The further metabolism of AcAA, which had been regarded as one of the final metabolic products of aminopyrine, was especially enhanced by 3-mcthylcholanthrene pretreatment.
- 公益社団法人日本薬学会の論文
- 1987-08-25
著者
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tanaka T
Department Of Biopharmaceutics Faculty Of Pharmacy & Pharmaveutical Sciences Fukuyama University
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Tanaka T
Institute For Health Care Science Suntory Ltd.
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Tanaka T
Suntory Consumer Health Products Division
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IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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KANEO YOSHIHARU
Faculty of Pharmaceutical Sciences, Kyushu University
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Kaneo Yoshiharu
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Kaneo Yoshiharu
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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TANAKA TETUSRO
Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
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GOROMARU TSUYOSHI
Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
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Goromaru Tsuyoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Goromaru Tsuyoshi
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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