PRODUCT INHIBITION OF AMINOPYRINE N-DEMETHYLATION IN ISOLATED HEPATOCYTES
スポンサーリンク
概要
- 論文の詳細を見る
The product inhibition of aminopyrine (AM) N-demethylation by 4-monomethylaminoantipyrine (MAA) was examined in vitro in preparations of isolated rat hepatocytes using gas chromatograph-mass spectrometer (GC-MS). the kinetic study of AM N-demethylation, which was determined by MAA formation, was studied at concentrations from 0.2 to 4.0 mM with or without various concentrations of D_3-MAA.D_3-MAA inhibited AM N-demethylation non-competitively at concentrations of 0.2 to 1.0 mM of AM (k_i=1.81 m_M), though it did competitively at concentations of 1.0 to 4.0 mM of AM (K_i=0.81 mM). From the present observation, it was suggested that the inhibition type of AM N-demethylation by D_3-MAA was dependent on the substrate (AM) concentration.
- 公益社団法人日本薬学会の論文
著者
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NODA Atsuko
Faculty of Pharmaceutical Sciences, Kyushu University
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GOTO SHIGERU
Faculty of Pharmaceutical Sciences, Okayama University
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Tabata Tetsuro
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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MATSUYAMA KENJI
Faculty of Pharmaceutical Sciences, Kyushu University
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IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Matsuyama Kenji
Faculty Of Pharmaceutical Sciences Kyushu University
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Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda H
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Iguchi Sadao
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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Goto S
Faculty Of Pharmaceutical Sciences Kyushu University
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TANAKA TETSUROU
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Goto Shigeru
Faculty Of Pharmaceutical Science Kyushu University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Goto Shigeru
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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