BIOHYDROXYLATION OF AMINOPYRINE : QUANTITATIVE STUDIES OF 3-HYDROXYMETHYL METABOLITE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Significance of the formation of 4-dimethylamino-3-hydroxymethyl-2-methyl-1-phenyl-3-pyrazolin-5-one (AM-3-CH_2OH) for the metabolism of AM was examined quantitatively in rats. Although urinary excretion of AM-3-CH_2OH accounted for only 0.7% to the dose, incubation of AM in the isolated hepatocyte system resulted in the formation of 9% of AM-3-CH_2OH. Furthermore, metabolic disappearance of AM-3-CH_2OH in the same system was fast, indicating the properties of an intermediate metabolite. These results suggested that the metabolic pathways via AM-3-CH_2OH are very important in the metabolism of AM.
- 公益社団法人日本薬学会の論文
著者
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Tanaka Tetsuro
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Tanaka T
Department Of Biopharmaceutics Faculty Of Pharmacy & Pharmaveutical Sciences Fukuyama University
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IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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KANEO YOSHIHARU
Faculty of Pharmaceutical Sciences, Kyushu University
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Kaneo Yoshiharu
Laboratory Of Biopharmaceutics Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Kaneo Yoshiharu
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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GOROMARU TSUYOSHI
Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
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TANAKA TETSURO
Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
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Goromaru Tsuyoshi
Faculty Of Pharmaceutical Sciences Kyushu University
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Goromaru Tsuyoshi
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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