INFLUENCE OF PHENOBARBITAL AND 3-METHYLCHOLANTHRENE ON THE METABOLISM OF AMINOPYRINE IN ISOLATED HEPATOCYTE SYSTEM
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概要
- 論文の詳細を見る
The effect of phenobarbital (PB) and 3-methylcholanthrene (3-MC) on the metabolic behavior of aminopyrine (AM) was studied using an isolated hepatocyte system prepared from male Wistar rats. The formation of 4-formylaminoantipyrine (FAA) was increased after pretreatment with PB, but not 3-MC. However, the total amounts of AM and its main metabolites recovered from hepatocyte system after the incubation for 30 min were considerably reduced both by PB and 3-MC-pretreatment. Furthermore, when using 4- monomethylaminoantipyrine (MAA), the first metabolite of AM, as a substrate, 3-MC-pretreatment resulted in a more significant decrease in the total amounts of MAA and its further metabolites recovered than did PB. Present observation suggests the participation of cytochrome P-448 as well as cytochrome P-450 in the metabolism of AM.
- 公益社団法人日本薬学会の論文
著者
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NODA Atsuko
Faculty of Pharmaceutical Sciences, Kyushu University
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GOTO SHIGERU
Faculty of Pharmaceutical Sciences, Okayama University
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Tabata Tetsuro
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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MATSUYAMA KENJI
Faculty of Pharmaceutical Sciences, Kyushu University
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IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Matsuyama Kenji
Faculty Of Pharmaceutical Sciences Kyushu University
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Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda H
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Iguchi Sadao
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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Goto S
Faculty Of Pharmaceutical Sciences Kyushu University
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TANAKA TETSUROU
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Goto Shigeru
Faculty Of Pharmaceutical Science Kyushu University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Goto Shigeru
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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