DISPLACING EFFECTS OF CHENODEOXYCHOLIC ACID, URSODEOXYCHOLIC ACID AND SULFADIMETHOXINE ON PLASMA PROTEIN BINDING OF TOLBUTAMIDE
スポンサーリンク
概要
- 論文の詳細を見る
The interactions between chenodeoxycholic acid (CDCA) or ursodeoxycholic acid (UDCA) and tolbutamide including its displacement from plasma protein binding sites were investigated pharmacokinetically. An increasing concentration of unbound tolbutamide was observed in the in vitro experiment, conducted by equilibrium dialysis method at 30℃ after the addition of CDCA and UDCA to human serum albumin (HSA), bovine serum albumin (BSA) and rabbit plasma containing tolbutamide. Small changes in total plasama concentration of tolbutamide were noted after high dose (0.167 mg/kg/min) intravenous infusion of CDCA to rabbits receiving a constant intravenous infusion of tolbutamide, but, such an observation was not obtained with low dose (0.083 mg/kg/min) of CDCA or with either high or low dose of UDCA. These results seem to indicate the displacement of high doses of CDCA. The coadiministration of sulfadimethoxine which not only displaces tolbutamide from binding sites but also inhibits its metabolism was investigated. A different plasma pattern was obtained under the same intravenous infusion conditions, as compared with the plasma pattern resulting from tolbutamide-CDCA or UDCA combination.
- 公益社団法人日本薬学会の論文
著者
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Watanabe S
Faculty Of Pharmaceutical Science Kyushu University
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Goto Shigeru
Faculty Of Pharmaceutical Science Kyushu University
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WATANABE SHUNSUKE
Faculty of Pharmaceutical Science, Kyushu University
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MAEHARA SHINICHI
Faculty of Pharmaceutical Science, Kyushu University
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NAKATA YUICHIRO
Faculty of Pharmaceutical Sciences, Okayama University
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TATEYAMA TADASHI
Eizai Research Laboratories
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Tateyama T
Eizai Research Laboratories
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Maehara Shinichi
Faculty Of Pharmaceutical Science Kyushu University
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Nakata Yuichiro
Faculty Of Pharmaceutical Sciences Okayama University
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