Double Fluorescent Labeling Method Used for a Study on Liposomes (II) : On the particle size of Liposomes Containing Carboxyfluorescein or Calcein

概要

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By using the double fluorescent labeling method of the previous report, the size of liposome entrapping carboxyfluorescein(CF), which was prepared by the sonification method, was compared with that of calcein(CAL). As a result, it was revealed that the size of CF-liposomes was always smaller than the size of CAL-liposomes in every preparations and the entrapment efficiencies of CF-liposomes were always lower than those of CAL-liposomes. The results obtained in this study suggest that the diameter and the entrapment effciency of lipospmes would be influenced by the molecular size and structure of drugs entrapped in liposomes. Therefore, it will be necessary to consider the above-mentioned evidence when liposomes are prepared and used for a drug delivery system(DDS).
九州大学の論文