TISSUE DISTRIBUTION OF ISONIAZID AND ITS METABOLITES IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
Distribution of isoniazid and its metabolites was observed in the liver, kidney, lung and plasma after the subcutaneous administration of isoniazid to rats. The tissue levels of isoniazid, acetylisoniazid, acetylhydrazine, 1,2-diacetylhydrazine and hydrazine were determined by mass fragmentography using a gas chromatograph-mass spectrometer equipped with a multiple ion detecter-peak matcher. Using the compounds labeled with a stable isotope as an internal standard, namely the isotope dilution method, made it possible to estimate trace amounts of these metabolites in the tissues. The amount of hydrazine was much less than the other hydrazines, but the metabolite which is well known as a mutagen, could be successfully detected in the tissues and plasma. The greater part of free hydrazine is formed through a direct hydrolysis of isoniazid. The isoniazid-hydrolyzing activity was found to be significantly higher in the liver homogenate. This suggested that hydrazine formation is mainly caused by hepatic hydrolysis.
- 公益社団法人日本薬学会の論文
著者
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NODA Atsuko
Faculty of Pharmaceutical Sciences, Kyushu University
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Tabata Tetsuro
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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MATSUYAMA KENJI
Faculty of Pharmaceutical Sciences, Kyushu University
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IGUCHI SADAO
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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Matsuyama Kenji
Faculty Of Pharmaceutical Sciences Kyushu University
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Matsuyama Kenji
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Matsuyama Kenji
Department Of Hospital Pharmacy Nagasaki University Hospital:faculty Of Pharmaceutical Sciences Kyus
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Matsuyama K
Department Of Clinical Pharmacy Kyoritsu University Of Pharmacy
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda H
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda Atsuko
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Iguchi Sadao
Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University
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Iguchi Sadao
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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Kubo Hiroaki
Faculty Of Pharmaceutical Sciences Kyushu University
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KANEO YOSHIHARU
Faculty of Pharmaceutical Sciences, Kyushu University
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Kaneo Yoshiharu
Faculty Of Pharmacy & Pharmaceutical Sciences Fukuyama University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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Noda A
Faculty Of Pharmaceutical Sciences Kyushu University School Of Medicine Kyushu University:department
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