Pharmacokinetic Study of Allixin, a Phytoalexin Produced by Garlic
スポンサーリンク
概要
- 論文の詳細を見る
The pharmacokinetic behavior of allixin (3-hydroxy-5-methoxy-6-methyl-2-penthyl-4H-pyran-4-one) was investigated in an experimental animal, mice. Allixin was administered using an inclusion compound because the solubility of allixin in aqueous solution is very low. The allixin content in serum and in the organs of administered animals was analyzed by liquid chromatography (LC)-MS. Most of the administered allixin disappeared within 2h, and the bioavailability of allixin was estimated to be 31% by obtained area under the blood concentration-time curve (AUC). The metabolites of allixin were studied using the metabolic enzyme fraction of liver and liver homogenate. Several new peaks corresponding to allixin metabolites were observed in the HPLC chromatoprofile. The chemical structure of the metabolites was investigated using LC-MS and NMR. Three of them were identified as allixin metabolites having a hydroxylated pentyl group.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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ONO Kazuhisa
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Kashimoto Naoki
湧永製薬
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Kashimoto Naoki
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Kashimoto Naoki
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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ICHIKAWA Makoto
Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.
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KODERA Yukihiro
Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.
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Ichikawa M
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Ichikawa Makoto
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Ichikawa M
Faculty Of Engineering Yamaguchi University
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Ono Kazuhisa
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Ono Kazuhisa
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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IDE Nagatoshi
Healthcare Research Institute, Wakunaga Pharmaceutical Co., Ltd.
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YOSHIDA Jiro
Healthcare Institute, Wakunaga Pharmaceutical Co., Ltd.
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UDA Naoto
Healthcare Institute, Wakunaga Pharmaceutical Co., Ltd.
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SUMIOKA Isao
Healthcare Institute, Wakunaga Pharmaceutical Co., Ltd.
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Kodera Yukihiro
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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Uda Naoto
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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Sumioka Isao
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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Yoshida J
Furukawa Electric Co. Ltd. Yokohama Jpn
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Yoshida J
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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Yoshida Jiro
Healthcare Institute Wakunaga Pharmaceutical Co. Ltd.
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Ide Nagatoshi
Healthcare Research Institute Wakunaga Pharmaceutical Co. Ltd.
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Kodera Yukihiko
Healthcare Institute, Wakunaga Pharmaceutical Co., Ltd.
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