A New Lipid Transfer Protein Homolog Identified as an IgE-Binding Antigen from Japanese Cedar Pollen
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概要
- 論文の詳細を見る
Japanese cedar (Cryptomeria japonica) pollen is a major cause of seasonal rhinitis and conjunctivitis in Japan, and an understanding of its full allergen repertoire is prerequisite for the development of future molecular diagnostics and immunotherapeutic strategies. Here we report the identification of a new C. japonica pollen IgE-binding antigen (CJP-8) homologous to lipid transfer proteins (LTPs), a class of plant cross-reactive allergens found in foods, latex, and pollen grains. The cjp-8 cDNA encodes a 165-amino acid polypeptide possessing the conserved eight cysteines characteristic of plant LTP family members. Escherichia coli-expressed recombinant CJP-8 (r-CJP-8) reacted with IgE antibody from Japanese cedar pollinosis patients at a 37.5% frequency (6/16).
著者
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Ibrahim Ahmed
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Kawamoto Seiji
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Nishimura Minori
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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PAK Syunka
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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AKI Tsunehiro
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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DIAZ-PERALES Araceli
Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Polite
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SALCEDO Gabriel
Unidad de Bioquimica, Departamento de Biotecnologia, E.T.S. Ingenieros Agronomos, Universidad Polite
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ASTURIAS Juan
Research and Development Department, Bial-Aristegui
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HAYASHI Takaharu
Takanobashi Central Hospital
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ONO Kazuhisa
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Kawamoto Seiji
Graduate School Of Advanced Sciences Of Matter Hiroshima University
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