Lack of Effect of the Abnormal Fatty Acid Metabolism in NC/Nga Mice on Their Atopic Dermatitis
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概要
- 論文の詳細を見る
Although clinical evidence has suggested that dysregulated fatty acid metabolism is associated with atopic disorders, the molecular basis for such a correlation remains to be demonstrated. In the present study, we analyzed the fatty acid composition in peripheral blood cells of NC/Nga mice, a model for atopic dermatitis (AD). We found that arachidonic acid significantly accumulated in mice with the AD manifestation. In addition, the leucotriene B_4-releasing ability upon calcium inophore A23187 stimulation was potentiated in blood cells. An arachidonic acid accumulation was not apparent in the non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice fed under specific pathogen-free conditions. These results indicate that a disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for their dermatitis development.
- 社団法人日本農芸化学会の論文
- 2001-02-23
著者
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Kawamoto Seiji
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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AKI Tsunehiro
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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ONO Kazuhisa
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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鈴木 修
池浦特許事務所
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Kawamoto Seiji
台湾
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Kawamoto Seiji
Graduate School Of Advanced Sciences Of Matter Hiroshima University
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秋 庸裕
Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.
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SUZUKI Osamu
Department of Fermentation Technology, Hiroshima University
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Suzuki O
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Suzuki Osamu
Department Of Cardiology Iwate Prefectural Iwai Hospital
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Suzuki O
Department Of Legal Medicine Hamamatsu University School Of Medicine
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Ono Kazuhisa
Dep. Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Univ.
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Ono Kazuhisa
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Shigeta S
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Shigeta Seiko
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Sato O
Second Department Of Surgery Faculty Of Medicine The University Of Tokyo
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Suzuki O
Department Of Veterinary Science National Institute Of Infectious Diseases
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Suzuki O
Second Department Of Surgery Yamanashi Medical University
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KITA Maiko
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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HAMADA Mizuho
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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Kita Maiko
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Hamada Mizuho
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Aki Tsunehiro
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Kawamoto Seiji
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Suzuki Osamu
Department Of Veterinary Science National Institute Of Infectious Diseases
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Ono Kazuhisa
Department Of Molecular Biotechnology Graduate School Of Advanced Sciences Of Matter Hiroshima Unive
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Kawamoto Seiji
Department of Chemistry, Faculty of Science, Osaka University
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