Elevation of Serum Thioredoxin in Patients with Gefitinib-induced Interstitial Lung Disease
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概要
- 論文の詳細を見る
Objective Interstitial lung disease (ILD) is a severe adverse event of gefitinib therapy. However, the mechanism still remains unclear. The objective of this study was to examine whether or not oxidative stress, one of the common factors in drug-associated ILD, is involved in the pathogenesis of gefitinib-induced ILD. Patients and Methods Using an enzyme-linked immunosorbent assay (ELISA), we measured the concentration of serum thioredoxin (Trx), a redox-active protein with antioxidative effects, in 44 patients treated with gefitinib, including three patients who had ILD. Results In patients who had gefitinib-induced ILD, serum Trx levels were significantly elevated. They decreased after cessation of gefitinib therapy accompanying clinical improvement of ILD. Conclusion It was suggested that oxidative stress may be involved as a part of mechanisms causing or worsening gefitinib-induced ILD.
- 社団法人 日本内科学会の論文
著者
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Yodoi Junji
Department Of Biological Responses Institute For Virus Research Kyoto University
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Hoshino Yuma
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University
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Mishima Michiaki
Department Of Respiratory Medicine Graduate School Of Medicine Kyoto University
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Mio Tadashi
Department Of Respiratory Medicine Graduate School Of Medicine Kyoto University
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Sakuma Keiichiro
Department Of Molecular Pathology Research Institute Aichi Cancer Center
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Masago Katsuhiro
Department Of Respiratory Medicine Graduate School Of Medicine Kyoto University
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Fujita Shiro
Department Of Applied Physics & Physico-informatics Graduate School Of Science And Technology Ke
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Nakamura Hajime
Department Of Biological Responses Institute For Virus Research Kyoto University
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Nakamura Takayuki
Department Of Chemistry Tokyo Gakugei University
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UEDA Shugo
Department of Gastroenterological Surgery, Tazuke Kofukai Medical Research Institute, Kitano Hospital
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Tabata Chiharu
Department of Internal Medicine, Division of Respiratory Medicine, Hyogo College of Medicine
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ICHIKAWA MASATAKA
Department of Chemical Engineering, Kyushu University
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Fujita Shiro
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine
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Mio Tadashi
Department of Respiratory Medicine, Kyoto University Graduate School of Medicine
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