Yeast Thioredoxin-Enriched Extracts for Mitigating the Allergenicity of Foods
スポンサーリンク
概要
- 論文の詳細を見る
Thioredoxin (TRX) catalyzes the reduction of disulfide bonds in proteins via the NADPH-dependent thioredoxin reductase system. Reducing the disulfide bonds of allergenic proteins in food by TRX lowers the allergenicity. We established in this study a method to prepare TRX-enriched extracts from the edible yeast, Saccharomyces cerevisiae, on a large and practical scale, with the objective of developing TRX-containing functional foods to mitigate food allergy. Treating with the yeast TRX-enriched extracts together with NADPH and yeast thioredoxin reductase enhanced the pepsin cleavage of β-lactoglobulin and ovomucoid (OM). We also examined whether yeast TRX can mitigate the allergenicity of OM by conducting immediate allergy tests on guinea pigs. The treatment with TRX reduced the anaphylactic symptoms induced by OM in these tests. These results indicate that yeast TRX was beneficial against food allergy, raising the possibility that yeast TRX-enriched extracts can be applied to food materials for mitigating food allergy.
- 社団法人 日本農芸化学会の論文
著者
-
Yodoi Junji
Department Of Biological Responses Institute For Virus Research Kyoto University
-
Masutani Hiroshi
Department Of Biological Responses Institute For Virus Research Kyoto University
-
Nakamura Hajime
Department Of Biological Responses Institute For Virus Research Kyoto University
-
Yasuda Hisataka
Nagahama Institute For Biochemical Science Oriental Yeast Co. Ltd.
-
TAKETANI Yukiko
Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.
-
KINUGASA Kimihiro
Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.
-
FURUKAWA Shuhei
Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.
-
OTSUKI Ryoko
Department of Biological Responses, Institute for Virus Research, Kyoto University
-
FUJITA Tuyosi
Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.
-
KANZAKI Ken
Nagahama Institute for Biochemical Science, Oriental Yeast Co., Ltd.
関連論文
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Enigma of oxidative stress in benzene induced hematotoxicity answered by thioredoxin-overexpression mouse(Blood, Biomarker, Proceedings of the 32nd Annual Meeting)
- Complete skipping of exon 66 due to novel mutations of the dystrophin gene was identified in two Japanese families of Duchenne muscular dystrophy with severe mental retardation
- Bio-molecular model for cancer prevention : Attenuation of oxidative stress by thioredoxin over-expression to reduce the benzene leukemia (BLOOD SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Crystal Structure and Hydrogen Absorption Properties of La(Ni, M)_x(M=Al, Co, Mn, Si. x=3-7)Melt-Spun Ribbons
- Overexpression of thioredoxin in transgenic mice attenuates adriamycin-induced cardiomyopathy
- OE-230 Acute Myocardial Infarction with High Level of Remnant-like Lipoproteins Particles Cholesterol Has More Potent Vulnerable Plaques at the Culprit Lesion(Acute myocardial infarction, clinical (pathophysiology)-1 (IHD) OE39,Oral Presentation (English)
- OE-185 Serum Level of Remnant-like Lipoproteins Particles Cholesterol can be a Predictor of Vasospastic Angina Pectoris(Angina pectoris, basic/clinical-1 (IHD) OE31,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese
- OE-033 Amount of Thrombus in Culprit Lesion is in Proportion to Serum hs-CRP Level at 1 Month after Myocardial Infarction Onset(Acute myocardial infarction, clinical (diagnosis/treatment)-1 (IHD) OE6,Oral Presentation (English),The 70th Anniversary Annual
- Recent Decline in Hospital Mortality Among Patients With Acute Myocardial Infarction
- Higher Remnant-like Lipoproteins Particles Cholesterol Levels Make Plaques-thrombi Complex Volume Greater at the Culprit Lesion of Acute Myocardial Infarction (Acute Myocardial Infarction, Clinical (Pathophysiology) 7 (IHD), The 69th Annual Scientific Mee
- Thioredoxin and Oxidized Lipoprotein are Increased in Unstable Plaque Obtained by Directional Coronary Atherectomy(Angina Pectoris, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-027 Thioredoxin in Coronary Culprit Lesions : Possible Relationship to Oxidative Stress and Intraplaque Hemorrhage(Angina pectoris, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Thioredoxin Reductase 1 Is Important for Selenoprotein Biosynthesis in HeLa Cells
- Difference in Thioredoxin Expression in Viral Myocarditis in Inbred Strains of Mice
- Serum Thioredoxin (TRX) Levels in Patients With Heart Failure
- PJ-164 A Hypertensive Response to Exercise May Cause Wall Motion Abnormalities in the Absence of Coronary Artery disease(Echo/Doppler-12 (I) PJ28,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-145 Utility of exercise echocardiography using hand-carried cardiac ultrasound (HCU) device for diagnosing coronary artery diseases(Echo/Doppler 1 (I) : PJ24)(Poster Session (Japanese))
- Ligation of Medically Refracted Patent Ductus Arteriosus (PDA) in an Extremely Low Body Weight Premature Infant
- Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance
- GHz Range Electromagnetic Wave Absorption Properties of M and W-Type Two Phase Hexaferrite
- Compositional Dependence of the Electromagnetic Wave Absorption Properties of BaFe_Ti_xMn_yO_ in the GHz Frequency Range
- Barium M-type Ferrite as an Electromagnetic Microwave Absorber in the GHz Range
- Non-Ruptured Eroded Plaque in the Culprit Lesion Develops Less Neointimal Proliferation after Stenting Compared with Ruptured Plaque
- Ischemia-Related Lesion Characteristics in Patients with Vasospastic Angina : Analysis by Angioscopy and Intravascular Ultrasound
- Clinical Differences of Ruptured Plaque and Non-Ruptured Plaque of Culprit Lesions in Patients with Unstable Angina Pectoris
- Human V5 demonstrated by magnetoencephalography using random dot kinematograms of different coherence levels
- Influence of Substrate Materials upon Fabrication of Aluminum Nitride Coatings by Reactive RF Plasma Spraying
- Pharmacokinetics of Pirarubicin in Pediatric Patients
- Adenovirus-Mediated Transduction of Escherichia coli Uracil Phosphoribosyltransferase Gene Increases the Sensitivity of Esophageal Cancer Cells to 5-Fluorouracil
- Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin : A Case Report
- タイ国のGilbert症候群患者姉妹のUGT1A1遺伝子に認められた新しいミスセンス異変
- Pharmacokinetics of Zonisamide ; Saturable Distribution into Human and Rat Erythrocytes and into Rat Brain
- 新生児慢性肺疾患に対するデキサメサゾン療法が呼吸機能に及ぼす効果 : 病型別検討
- Expression of the Adult T-cell Leukemia-Derived Factor, Human Thioredoxin, in the Allotransplanted Canine Lung
- Serum 8-Hydroxy-2'-Deoxyguanosine (8-OHdG), a Marker of Oxidative Damage to DNA, Is Elevated in Patients with Heart Failure
- The Effect of Co on HDDR Phenomena in the Sm_3(Fe,V)_ Compound
- An Investigation of HDDR Phenomena in the Sm_3(Fe, V)_ Compound
- Microstructural changes in Nd_2Fe_B permanent magnet alloys during HDDR phenomena
- N-acetylcysteine improves cytotoxic activity of cirrhotic rat liver-associated mononuclear cells
- Elevation of plasma thioredoxin levels in HIV-infected individuals
- Control of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis : a pilot study
- Cutaneous Arteriolar Thioredoxin Expression in Patients With Heart Failure
- Efficacy of antibiotics against influenza-like illness in an influenza epidemic
- Thioredoxin and its binding proteins : Biological significance of these interactions
- Eyelid myoclonia with absences in monozygotic twins
- Pallister-Mosaic syndrome and neuronal migration disorder
- Clinical features of infants with subependymal germinolysis and choroid plexus cysts
- A novel cryptic exon in intron 3 of the dystrophin gene was incorporated into dystrophin mRNA with a single nucleotide deletion in exon 5
- Oligonucleotides against a splicing enhancer sequence led to dystrophin production in muscle cells from a Duchenne muscular dystrophy patient
- End-tidal carbon monoxide is predictive for neonatal non-hemolytic hyperbilirubinemia
- Non-homologous recombination between Alu and LINE-1 repeats caused a 430-kb deletion in the dystrophin gene : a novel source of genomic instability
- A simple explanation for a case of incompatibility with the reading frame theory in Duchenne muscular dystrophy: failure to detect an aberrant restriction fragment in Southern blot analysis
- Vascular involvement in benign infantile mitochondrial myopathy caused by reversible cytochrobe c oxidase dificiency
- Severe neonatal nemaline myopathy with delayed maturation of muscle
- Preventive effects of dexamethasone on hypoxic-ischemic brain damage in the neonatal rat
- Association of microRNA-34a overexpression with proliferation is cell type-dependent
- Hydrogen Absorption Properties of Amorphous and Crystalline La-Ni-B Melt-Spun Ribbons
- Phase Relation of Sm-Fe-V Alloys around the Compound Sm_3(Fe, V)_
- GAS-LIQUID TURBULENT TWO PHASE FLOW ALONG VERTICAL FLAT PLATE WITH GAS EVOLUTION
- Phase II Trial of 5-Fluorouracil and Low-Dose Cisplatin in Patients with Squamous Cell Carcinoma of the Esophagus
- Two cases of colonic necrosis following aortoiliac surgery due to coronary-induced cardiogenic shock
- Neonatal Renal Artery Blood Flow Velocities Using Color Doppler Ultrasonography
- IS009 GATA-5 Is Involved in Leukemia Inhibitory Factor-Induced Hypertrophy Signalling in Cardiac Myocytes
- Factors Affecting Prognosis of Intrauterine Hydrocephalus Diagnosed in the Third Trimester : Computerized Data Analysis on Controversies in Fetal Surgery
- Thioredoxin Gene Expression in Rat Knee Articular Cartilage After Full-Thickness Injury
- "S1-1 Thioredoxin/Adult T-Cell Leukemia-Derived Factor (ADF) and Redox Regulation (Regulation of biological events and occurrence of toxicity with active oxygen species and NO)
- PSYCHOLOGICAL AND PHYSICAL REACTIONS ON CHILDREN AFTER THE HANSHIN-AWAJI EARTHQUAKE DISASTER (阪神淡路大震災後の子ども達における精神的及び身体的反応)
- Changes in thioredoxin concentrations : an observation in an ultra-marathon race
- THE EFFECT OF FREEZING AND MELTING ON THE EFFICIENCY OF LATENT HEAT STORAGE SYSTEMS
- F116 NUMERICAL SIMULATION OF UNSTEADY HEAT TRANSFER AROUND TWO CIRCULAR CYLINDERS ARRANGED IN TANDEM TO A UNIFORM FLOW BYA VORTEX AND HEAT ELEMENTS METHOD(Numerical methods-2)
- Activation of natural killer cells by the mAb YTA-1 that recognizes leukocyte function-associated antigen-1
- Effects of Combination of ACE Inhibitor and Angiotensin Receptor Blocker in Patients with Idiopathic Dilated Cardiomyopathy
- Fluid Flow and Local Heat Transfer around Two Cubes Arranged in Tandem on a Flat Plate Turbulent Boundary Layer
- Drag Reduction and Heat Transfer Enhancement of a Square Prism
- Fluid Flow and Heat Transfer around a Cylindrical Protuberance Mounted on a Flat Plate Boundary Layer
- Heat Transfer in Separated Flow behind a Circular Cylinder for Reynolds Numbers from 120 to 30000 : 2nd Report, Unsteady and Three-Dimensional Characteristics
- H103 PRESSURE DROP AND HEAT TRANSFER OF ARRAYS OF IN-LINE CIRCULAR BLOCKS ON THE WALL OF PARALLEL CHANNEL(Electronics cooling-1)
- Establishment of a new murine model of hypercalcemia with anorexia by overexpression of soluble receptor activator of NF-κB ligand using an adenovirus vector
- Induction of heat shock proteins and its effects on glial differentiation in rat C6 glioblastoma cells
- Time and Space-Resolved Heat Transfer in Separated Flow behind a Circular Cylinder for Reynolds Numbers from 100 to 30000
- Heat Transfer Enhancement of a Low-Profile Block in a Channel Flow at Low Air-Velocity
- Yeast Thioredoxin-Enriched Extracts for Mitigating the Allergenicity of Foods
- Yeast Thioredoxin-Enriched Extracts for Mitigating the Allergenicity of Foods
- Preface
- The discovery of ATL : an odyssey in restrospect
- Fluid Flow and Heat Transfer around a Rectangular Cylinder : The Case of a Width/Height Ratio of a Section of 5-9
- Attenuation of indomethacin-induced gastric mucosal injury by prophylactic administration of sake yeast-derived thioredoxin
- Elevation of Serum Thioredoxin in Patients with Gefitinib-induced Interstitial Lung Disease
- Combined free and forced laminar convection in thermal entrance region of horizontal triangular ducts.
- The effect of variable viscosity on laminar flow and heat transfer in rectangular ducts.
- Experimental study on heat transfer of combined free and forced laminar convection in thermal entrance region of horizontal rectangular ducts.
- Combined free and forced laminar convection in triangular ducts.
- Numerical method for solving steady three-dimensional heat conduction problem in sector column.
- Effect of Selenite on T-Cell Mitogenesis: Contribution of ROS Production and Apoptosis Signal-Regulating Kinase 1