Difference in Thioredoxin Expression in Viral Myocarditis in Inbred Strains of Mice
スポンサーリンク
概要
- 論文の詳細を見る
Redox regulating mechanisms may be involved in the pathogenesis of viral myocarditis and thioredoxin (TRX) is a small multifunctional protein that contains a redox active sequence. The present study investigated the histopathology and characteristics of TRX expression in acute coxsackievirus B3 myocarditis in inbred strains of mice (severe myocarditis in DBA/2 mice, moderate myocarditis in BALB/c mice and mild myocarditis in C57BL/6 mice). Thioredoxin was upregulated and its expression correlated with the severity of the disease. In addition, 8-hydroxy-2'-deoxyguanosine, which is an established marker for oxidative stress, was concominantly positive in damaged myocytes. Thus, TRX may be specifically induced by the acute inflammatory stimuli in murine viral myocarditis, and the severity and development of acute viral myocarditis may be regulated by the cellular redox state. (Jpn Circ J 2001; 65: 561-564)
- 2001-05-20
著者
-
KISHIMOTO Chiharu
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
-
YODOI Junji
Department of Biological Responses, Institute for Virus Research, Kyoto University
-
Kishimoto Chiharu
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Kishimoto Chiharu
Department Of Cardiology Shizuoka Central Prefectural Hospital Shizuoka
-
Kishimoto Chiharu
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
-
TOYOKUNI Shinya
Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University
-
NAKAMURA Hajime
Department of Pediatrics, Kobe University School of Medicine
-
Yodoi Junji
Institute Of Virus Research Kyoto University
-
Yodoi Junji
Department Of Biological Responses Institute For Virus Research Kyoto University
-
Sasayama S
Department Of Life And Medical Science Doshisha University Kyotanabe & Daijukai Hospital
-
Nakamura Hajime
Institute of Virus Research, Kyoto University
-
Sasayama Shigetake
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine
-
Shioji Keisuke
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Shioji Keisuke
Department Of Cardiology Kishiwada City Hospital
-
Saijyo Sayaka
Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
-
Sasayama Shigetake
The Third Division Of Medicine Kyoto University
-
Kishimoto Chiharu
Third Division Of Internal Medicine Kyoto Univercity Hospital.
-
KITA Masakazu
Department of Microbiology, Kyoto Prefectural University of Medicine
-
Miyamoto Miki
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
-
Miyamoto Miki
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Nakayama Yukie
Department of Cardiovascular Medicine, Graduate School of Medicine
-
Sasayama Shigetake
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Sasayama Shigetake
Division Of Medicine Hamamatsu Rosai Hospital Shizuoka
-
Toyokuni Shinya
Department Of Pathology And Biological Responses Graduate School Of Medicine Nagoya University
-
Kita Masakazu
Department Of Microbiology Kyoto Prefectural Medical University
-
Sasayama Shigetake
Department Of Cardiology Doshisha University
-
Saijyo Sayaka
The Department Of Cardiology Hyogo Prefectural Amagasaki Hospital
-
Shoji Keisuke
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Nakamura Hajime
Institute Of Virus Research Kyoto University
-
Nakamura Hajime
Department Of Biological Responses Institute For Virus Research Kyoto University
-
Kishimoto Chiharu
Department Of Cardiovascular Medicine Guraduate School Of Medicine Kyoto University
-
Nakayama Yukie
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
-
Sasayama Shigetake
Thesecond Department Of Internal Medicine Toyama Medical And Pharmaceutical University
-
Sawada Shigeo
Division Of Medicine Hamamatsu Rosai Hospital Shizuoka
-
Kita Masakazu
Department of Chemistry, Faculty of Science, Nagoya University
関連論文
- N-Acetylcysteine Reduces the Severity of Atherosclerosis in Apolipoprotein E-Deficient Mice by Reducing Superoxide Production
- PE-132 Induction of Vulnerable Plaques by Marble-Burying Behavior and Their Stabilization by Exercise Training in Experimental Atherosclerosis(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting
- PE-026 Swimming Reduces the Severity of Atherosclerosis in Apolipoprotein E Deficient Mice by Antioxidant Effects(Atherosclerosis, basic(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Exercise Training Reduces Severity of Atherosclerosis in Apolipoprotein E Knockout Mice via Nitric Oxide
- Electron Microscopical Evidence of the Protective Function of Thioredoxin (TRX/ADF) Transgene against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced Cellular Toxicity in the Liver and Brain
- Potent Antioxidative Activity of Vineatrol®30 Grapevine-shoot Extract
- PE-132 Induction of Vulnerable Plaques by Marble-Burying Behavior and Their Stabilization by Exercise Training in Experimental Atherosclerosis(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting
- DPE-011 Naloxone, an Opiate Receptor Antagonist, Ameliorates Acute Heart Failure in Experimental Autoimmune Myocarditis by Reducing Cytotoxic Activities(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- DPE-011 Naloxone, an Opiate Receptor Antagonist, Ameliorates Acute Heart Failure in Experimental Autoimmune Myocarditis by Reducing Cytotoxic Activities(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of
- Serum Thioredoxin and α-Tocopherol Concentrations in Patients With Major Risk Factors
- Serum thioredoxin levels in patients with coronary vasospasm and in subjects with various risk factors
- PE-132 Induction of Vulnerable Plaques by Marble-Burying Behavior and Their Stabilization by Exercise Training in Experimental Atherosclerosis(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting
- PE-422 Immunoglobulin Treatment Suppresses Oxidative Stress-Mediated Myocardial Injury in Autoimmune Heart Failure(Heart failure, basic(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-042 Therapy With Immunoglobulin Prevents Acute Death in Patients With Fulminant Myocarditis(Cardiomyopathy, basic/clinical(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-258 An Experimental Model of in Vitro Autoimmune-mediated Myocardial Damage in Myocarditis(Myocarditis, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-257 Antibody-Mediated Infectious Enhancement via Fc receptors in Murine Coxsackievirus B3 Myocarditis(Myocarditis, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-128 Effects of MCI-186 (edaravone), a Novel Free Radical Scavenger, upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice(Atherosclerosis, basic-6, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-075 Immunoglobulin Suppresses Experimental Atherosclerosis via the Fc Portion Independent of Hypercholesterolemia(Atherosclerosis, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-028 Generalized Oxidative Stress Overload is Present in Patients with Heart Failure(Clinical Heart Failure-Pathophysiology and Treatment, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of MCI-186 (Edaravone), a Novel Free Radical Scavenger, Upon Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice
- PJ-765 Carvedilol Protects against Autoimmune Heart Failure by Antioxidant Actions, But Not by Beta Blocking Effects(Heart failure, basic-8 (M) PJ132,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
- PE-429 Immunoglobulin Administration Ameliorated Left Ventricular Function in Patients with Myocarditis by Reducing Oxidative Stress(Myocarditis, basic/clinical-2 (M) PE72,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japa
- PE-428 Peroxisome Proliferation-Activated Receptor-γ Ligands Ameliorate Experimental Autoimmune Myocarditis(Myocarditis, basic/clinical-2 (M) PE72,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PE-183 Myocardial Oxidative Stress is Increased in Patients with Cardiomyopathies(Cardiomyopathy, basic/clinical-4 (M) PE31,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OE-288 Immunoglobulin Suppressed Autoimmune Myocarditis in Severe Combined Immunodeficient (SCID) Mice by Inducing T Cell Unresponsiveness(Myocarditis, basic/clinical-1 (M) OE49,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of
- Effects of Late Administration of Immunoglobulin on Experimental Atherosclerosis in Apolipoprotein E-Deficient Mice
- Significance of Pericardial Cytokines in Myocarditis (Myocarditis, Basic/Clinical 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- DNA Damage Is Increased in the Failing Human Myocardium Due to Myocarditis and Cardiomyopathies
- Immunoglobulin Suppressed Adoptively Transferred Autoimmune Myocarditis in Severe Combined Immunodeficient Mice : A Novel Suppressive Effect of Immunoglobulin on T Cells
- 28) PROGNOSIS OF IDIOPATHIC CARDIOMYOPATHY: ANALYSIS OF MULTICENTER REPORTS
- TEMOCAPRIAL TREATMENT AMELIORATES AUTOIMMUNE MYOCARDITIS IN RATS ASSOCIATED WITH ENHANCED CARDIOMYOCYTE THIOREDOXIN EXPRESSION
- Protection against Murine Coxsackievirus B3 Myocarditis by T Cell Vaccination
- OJ-052 Post-Myocarditic G-CSF Therapy Improves the Severity of the Disease in Experimental Autoimmune Myocarditis in Rats(Myocarditis, basic/clinical(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-320 Swimming Reduced the Severity of Atherosclerosis in Apolipoprotein E-deficient Mice(Atherosclerosis, Basic 5 (IHD) : PE55)(Poster Session (English))
- OE-113 Cardioprotective effects of MCI-186, a novel free radical scavenger, on acute autoimmune myocarditis(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- Beneficial Effects of Low-Dose Benidipine in Acute Autoimmune Myocarditis : Suppressive Effects on Inflammatory Cytokines and Inducible Nitric Oxide Synthase
- Immunoglobulin Treatment Suppresses Atherosclerosis in Apolipoprotein E Knockout Mice via the Fc Portion
- Cardioprotective Effects of Carvedilol on Acute Autoimmune Myocarditis : Anti-Inflammatory Effects Associated with Antioxidant Property
- Fc receptor-mediated inhibitory effect of immunoglobulin therapyupon autoimmune giant cell myocarditis
- Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with inflammatory cardiamyopathy
- Overexpression of thioredoxin in transgenic mice attenuates adriamycin-induced cardiomyopathy
- Immunoglobulin Therapy Improved Left Ventricular Function in Fulminant Myocarditis by the Reduction of Interleukin-6(Myocarditis, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Disappearence of Ventricular Tachyarrhythmas Is a Good Prognostic Marker in Immunoglobulin Therapy for Patients with Fulminant Myocarditis
- Treatment of inflammatory cardiomyopathy with immunoglobulin ameriorates ventricular function with suppression of cytokines and oxidative stress
- The Protection of Coenzyme Q_ against Experimental Viral Myocarditis in Mice : THE 8TH CONFERENCE ON PRVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- 5)SIGNIFICANCE OF SERIAL CHANGES OF SERUM CPK AND MYOCARDIAL CALCIUM CONTENT IN EXPERIMENTAL VIRAL MYOCARDITIS IN MICE : THE 7th CONFERENCE ON CARDIOMYOPATHY
- Overexpression of Integrin-associated Protein (CD47) in Rat Kidney Treated with a Renal Carcinogen, Ferric Nitrilotriacetate
- Low Incidence of Point Mutations in H- ,K- and N-ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate
- Thioredoxin and Oxidized Lipoprotein are Increased in Unstable Plaque Obtained by Directional Coronary Atherectomy(Angina Pectoris, Basic/Clinical 5 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-027 Thioredoxin in Coronary Culprit Lesions : Possible Relationship to Oxidative Stress and Intraplaque Hemorrhage(Angina pectoris, basic/clinical-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Thioredoxin Reductase 1 Is Important for Selenoprotein Biosynthesis in HeLa Cells
- Difference in Thioredoxin Expression in Viral Myocarditis in Inbred Strains of Mice
- Serum Thioredoxin (TRX) Levels in Patients With Heart Failure
- ELECTROCARDIOGRAPHIC FINDINGS OF ENCEPHALOMYOCARDITIS VIRAL MYOCARDITIS IN MICE : LOW VOLTAGE OF QRS COMPLEX IN SUBACUTE STAGE AND ARRHYTHMIAS IN CHRONIC STAGE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardi
- PE-366 Pioglitazone Ameliorates Atherosclerosis in Apolipoprotein E Deficient Mice by Modulating the Balance of Effector and Regulatory T Cells(PE062,Atherosclerosis (Clinical/Treatment) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of
- Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance
- Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas
- Evaluation of Arteriolar Hyalinosis of the Skin of Patients With Chronic Congestive Heart Failure
- PJ-628 Oxidant Stress-Mediated Myocardial Cell Injury in Selenium-Deficient Mice : Age-Dependent Roles of Glutathion Peroxidase Inhibition(Cardiomyopathy, Basic and Clinical 2 (M) : PJ105)(Poster Session (Japanese))
- PE-162 Serum Thioredoxin Concentrations and Cutaneous Arteriolar Hyalinosis with Thioredoxin Expression are Increased in Patients with Heart Failure(Heart Failure, Clinical 4 (M) : PE28)(Poster Session (English))
- FAMILIAL CONGESTIVE CARDIOMYOPATHY WITH POSITIVE RHEUMATOID FACTOR : REPORT OF ONE FAMILY.
- IDIOPATHIC CARDIOMYOPATHY AND HL-A : Cardiomyopathies, Kawasaki Disease : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Successful Immunoglobulin Treatment for Fulminant Myocarditis and Serial Analysis of Serum Thioredoxin : A Case Report
- Increased arteriolar hyalinosis and thioredoxin expression of skin in patients with chronic heart failure
- Expression of the Adult T-cell Leukemia-Derived Factor, Human Thioredoxin, in the Allotransplanted Canine Lung
- 17)SIGNIFICANCE OF HLA ANALYSIS AND PENETRANCE OF ASH IN FAMILIAL CARDIOMYOPATHY WITH COEXISTING HYPERTROPHIC AND DILATED-LIKE TYPES IN TWO FAMILIES : THE 8th CONFERENCE ON CARIDIOMYOPATHY
- Right Ventricular Aneurysms Complicating Encephalomyocarditis Virus Myocarditis in Mice : THE 7th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- Electrocardiographic Findings in Experimental Murine Myocarditis : Arrhythmias in the Chronic Stage : THE 7th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- AN ANIMAL MODEL OF CONGESTIVE (DILATED) CARDIOMYOPATHY : DILATATION AND HYPERTROPHY OF THE HEART IN THE CHRONIC STAGE IN DBA/2 MICE WITH MYOCARDITIS CAUSED BY ENCEPHALOMYOCARDITIS VIRUS : Cardiomyopathy (I) : 46th Annual Scientific Meeting, Japanese Circu
- 12) HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY IN THE ELDERLY
- 2) ELECTROCARDIOGRAPHIC FINDINGS IN EXPERIMENTAL MYOCARDITIS : a) ENCEPHALOMYOCARDITIS VIRUS MYOCARDITIS IN MICE b) COXSACKIE B_1 VIRUS MYOCARDITIS IN GOLDEN HAMSTERS
- A CASE OF MYOCARDITIS WITH IMMUNOLOGICAL IDENTIFICATION OF MYOCARDIAL AND PERIPHERAL LYMPHOCYTE SUBSETS
- Elevation of plasma thioredoxin levels in HIV-infected individuals
- Significance of Pericardial Cytokines in Giant Cell Myocarditis in Rats : Pathological Comparison to Viral Myocarditis in Mice
- Strain Difference in Rats With Experimental Giant Cell Myocarditis
- Control of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis : a pilot study
- Cutaneous Arteriolar Hyalinosis with Thioredoxin Expression Is Increased in Patients with Heart Failure
- Cutaneous Arteriolar Thioredoxin Expression in Patients With Heart Failure
- Thioredoxin and its binding proteins : Biological significance of these interactions
- 10) IMPROVED CINEANGIOGRAPHIC EVALUATION OF HYPERTROPHIC CARDIOMYOPATHY BY ANGLEDBIVENTRICULOGRAPHY
- MYOCARDIAL CONTRACTILE PROTEINS IN CARDIOMYOPATHY : A BIOPSY STUDY : Myocardial Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 26) ANALYSIS OF ARRHYTHMIAS BY 24-HOUR ELECTROCARDIOGRAPHIC MONITORING IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
- Mural Thrombi in Mice with Acute Viral Myocarditis : THE 9th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- IMMUNOLOGICAL BACKGROUNDS IN PATIENTS WITH DILATED CARDIOMYOPATHY AND MYOCARDITIS : CLINICAL AND EXPERIMENTAL STUDIES : Myocardial Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- EFFECTS OF PREDNISOLONE ON EXPERIMENTAL VIRAL MYOCARDITIS IN MICE : Cardiomyopathy : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- EFFECTS OF COENZYME Q_ ON EXPERIMENTAL VIRAL MYOCARDITIS IN MICE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiomyopathy
- 14) EFFECTS OF PREDNISOLONE ON EXPERIMENTAL MYOCARDITIS
- HLA-DR ANTIGEN LINKAGE IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY : Cardiomyopathy : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- 1) SILENT MYOCARDITIS IN BALB/c-NU/NU MICE
- 1)SIGNIFICANCE OF T-AND B-LYMPHOCYTES IN EXPERIMENTAL VIRAL MYOCARDITIS IN MICE : THE 8th CONFERENCE ON CARIDIOMYOPATHY
- IMMUNOLOGICAL BEHAVIOR OF LYMPHOCYTES IN EXPERIMENTAL VIRAL MYOCARDITIS : SIGNIFICANCE OF T-LYMPHOCYTES IN THE SEVERITY OF MYOCARDITIS AND SILENT MYOCARDITIS IN BALB/c-NU/NU MICE : Myocardial Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th
- Thioredoxin Gene Expression in Rat Knee Articular Cartilage After Full-Thickness Injury
- "S1-1 Thioredoxin/Adult T-Cell Leukemia-Derived Factor (ADF) and Redox Regulation (Regulation of biological events and occurrence of toxicity with active oxygen species and NO)
- Immunoglobulin Treatment Ameliorates Myocarditis Associated With Reduction of Neurohumoral Activity(Myocarditis, Basic/Clinical 1 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Changes in thioredoxin concentrations : an observation in an ultra-marathon race
- OJ-147 Immunoglobulin Treatment Ameliorates Murine Myocarditis Associated with Reduction of Neurohumoral Activity and Improvement of Extracellular Matrix Change(OJ25,Myocarditis, Basic/ Clinical (M),Oral Presentation (Japanese),The 73rd Annual Scientific
- The in Vivo Cardiotoxic Effect of Eosinophilic Cationic Protein in an Animal Preparation : THE 10th CONFERENCE ON THE 10th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE
- MURAL THROMBUS IN EXPERIMENTAL VIRAL MYOCARDITIS IN MICE : TIME OF APPEARANCE AND RELATIONSHIP BETWEEN THROMBOSIS AND CONGESTIVE HEART FAILURE : Myocardial Disease (I) : FREE COMMUNICATIONS (I) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JA
- Serial Electrocardiographic Changes in Fulminant Myocarditis