Beneficial Effects of Low-Dose Benidipine in Acute Autoimmune Myocarditis : Suppressive Effects on Inflammatory Cytokines and Inducible Nitric Oxide Synthase

概要

論文の詳細を見る
Excessive production of nitric oxide (NO) by inducible NO synthase (iNOS) contributes to the progression of myocardial damage in myocarditis. Some dihydropyridine calcium channel blockers reportedly inhibit NO production and proinflammatory cytokines and the present study sought to clarify if a low dose of benidipine, a novel dihydropyridine calcium channel blocker, would ameliorate experimental autoimmune myocarditis (EAM). Rats with or without myocarditis were administered oral benidipine at a dose of 3mg・kg^<-1>・day^<-1> for 3 weeks. Low-dose benidipine did not decrease blood pressure significantly compared with the untreated group, but markedly reduced the severity of myocarditis. Myocardial interleukin-1β (IL-1β) expression and IL-1β-positive cells were significantly less in rats with EAM that were treated with low-dose benidipine compared with untreated rats, Also, myocardial iNOS expression and iNOS-positive cells were markedly reduced in in the treated rats compared with the untreated group. Furthermore, myocardial NO production and nitrotyrosine expression were suppressed by the treatment in rats with EAM. The cardioprotection of low-dose benidipine may be caused by suppression of inflammatory cytokines and inhibition of NO production. (Circ J 2003; 67: 545-550)
社団法人日本循環器学会の論文
2003-05-20