Electrocardiographic Findings in Experimental Murine Myocarditis : Arrhythmias in the Chronic Stage : THE 7th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE

概要

論文の詳細を見る
We studied serial electrocardiographic changes in murine myocarditis due to encephalomyocarditis (EMC) virus. After taking control electrocardiograms using standard extremity and 2 precordial leads, 86 mice were intraperitoneally inoculated with a 0.1 ml of the M variant of EMC virus suspension containing 100 TCID_<50>. Electrocardiograms were recorded everyday from the 2nd to the 14th day, and thereafter once every 3-5 days until the 35th day. The cumulative incidence of myocarditis was 90% (77 out of 86). The control electrocardiogram showed a heart rate of 528 ± 87 beats/min (mean ± SD) and PR intervals of 0.03-0.05 sec, and significant rhythm or conduction disturbances were not found. Various electrocardiographic abnormalities, such as atrial (10%) and ventricular (21%) premature contractions, were noticed on the 4th to the 14th day. After 15-35 days arrhythmias still remained in 3 mice. The presence of arrhythmias in the chronic stage of myocarditis suggests that arrhythmias in some patients with no other clinical manifestations may be a sequela of the previous viral myocarditis. Thus, this study may contribute clinically to the clarification of the electrocardiographic characteristics in viral myocarditis.
社団法人日本循環器学会の論文
1983-11-20