Potent Antioxidative Activity of Vineatrol®30 Grapevine-shoot Extract

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概要

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• The health promoting effects of a grapevine-shoot extract named Vineatrol®30, which contains resveratrol (Resv) as well as considerable amounts of Resv oligomers, have recently been investigated. In the present study, we analyzed the free radical scavenging capacity, the ability to inhibit lipid peroxidation, and the capacity to enhance the human glutathione peroxidase 1 (GPx) and the human superoxide dismutase 1 (SOD) gene promoter activities of Vineatrol®30. Vineatrol®30 was able to scavenge the 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical cation and led to concentration-dependent inhibition of lipid peroxidation, Vineatrol®30 not being superior to Resv alone in both cases. Vineatrol®30 also enhanced the gene promoter activities of human GPx and SOD expressed in V79 cells, whereas this effect could not be demonstrated for Resv. In summary, the results presented in this study show that the Vineatrol®30 grapevine-shoot extract is a free radical scavenger and potent antioxidant at non-cytotoxic concentrations.

著者

• TOYOKUNI Shinya

  Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University

• Muller Carsten

  Chair of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam

• Ullmann Kristina

  Chair of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam

• Wilkens Andrea

  Institute of Food Chemistry, Technical University of Braunschweig

• WINTERHALTER Peter

  Institute of Food Chemistry, Technical University of Braunschweig

• STEINBERG Pablo

  Chair of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam

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