Increase in Oxidative Stress in Kidneys of Diabetic Akita Mice(Food & Nutrition Science)
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概要
- 論文の詳細を見る
New biomarkers for oxidative damage, were used to identify whether hyperglycemia caused oxidative stress in diabetic Akita mice. At 13 weeks of age, the tissues of these mice were obtained, and the levels of N^ε-(hexanonyl)lysine (HEL) and dityrosine (DT) were measured, these being related to lipid peroxide-derived protein covalent modification and protein cross-linking. The levels of HEL and DT in the kidneys of Akita mice were significantly increased compared with the control mice without any accumulation of thiobarbituric acid reactive substances and 4-hydroxy-2-nonenal-modified protein. Immunopositive staining was clearly observed in the kidneys of the Akita mice when using the anti-HEL antibody or anti-DT antibody. These results suggest that hyperglycemia in Akita mice induced oxidative stress and increased these markers in the kidneys.
- 社団法人日本農芸化学会の論文
- 2002-04-23
著者
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大沢 俊彦
名古屋大学大学院生命農学研究科
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TOYOKUNI Shinya
Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University
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Kato Yoji
Graduate School Of Human Sci. And Environment Univ. Of Hyogo
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Nomura H
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Horio F
Nagoya Univ. Nagoya Jpn
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Horio Fumihiko
Nagoya University Graduate School Of Bioagricultural Sciences
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Horio Fumihiko
Department Of Applied Molecular Biosciences Graduate School Of Bioagricultural Sciences Nagoya Unive
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KATO Yoji
School of Human Science and Environment, University of Hyogo
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OSAWA Toshihiko
Nagoya University Graduate School of Bioagricultural Sciences
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Osawa T
Nagoya University Graduate School Of Bioagricultural Sciences
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Osawa T
Laboratory Of Food And Biodynamics Nagoya University Graduate School Of Bioagricultural Sciences
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Osawa T
Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.
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UENO Yuki
Nagoya University Graduate School of Bioagricultural Sciences
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UCHIDA Koji
Nagoya University Graduate School of Bioagricultural Sciences
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NAITO Michitaka
Nagoya University, Graduate School of Medicine
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NOMURA Hideki
Nagoya University, Graduate School of Medicine
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TSUDA Takanori
Junior College Division, Tokaigakuen University
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Kato Yoji
School Of Human Science And Environment University Of Hyogo
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Kato Y
School Of Human Science And Environment University Of Hyogo
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Toyokuni S
Department Of Pathology And Biology Of Diseases Graduate School Of Medicine Kyoto University
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Toyokuni Shinya
Department Of Pathology And Biological Responses Graduate School Of Medicine Nagoya University
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Tsuda Takanori
Junior College Division Tokai Gakuen University
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Kato Yuriko
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Naito Michitaka
Division Of Nutrition & Health School And Graduate School Of Life Studies Sugiyama Jogakuen Univ
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Horio Fumihiko
Nagoya Univ. Nagoya Jpn
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