Classification of Lipoprotein Profile by Polyacrylamide Gel Disc Electrophoresis
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概要
- 論文の詳細を見る
Objective We studied the relationship between the polyacrylamide gel electrophoresis (PAGE) pattern of lipoproteins and other indicators of lipid metabolism. Materials and Methods Fasting serum lipid was analyzed in 108 Japanese hyperlipidemic and normolipidemic subjects (39 males and 69 females, 63.5±6.4 years old). We classified the lipoprotein profile by PAGE into the following four types (SAND); Type S (symmetric), Type A (asymmetric), Type N (nodular), and Type D (disrupted). The relationship between WHO classification of hyperlipidemias and SAND classification was analyzed. Results Normolipidemicsubjects were classified into Types S, A, and N. Type IIa subjects were classified into Types S, A, and N. Type IIb subjects were classified into Types S, A, N, and D. Type IV subjects were classified into Types N and D. Serum total cholesterol (TC) was not different among the SAND types, but serum triglyceride (TG) was significantly different among the types. Serum TG tended to increase from Type S to Type D. VLDL cholesterol (C) increased from Type S to Type D. LDL-C showed a trend to decrease from Type S to Type D, but without significance. HDL-C significantly decreased from Type S to Type D. VLDL-TG, LDL-TG, and HDL-TG increased from Type S to Type D. TC/TG, HDL-C/TG, LDL-C/LDL-TG, and HDL-C/HDL-TG ratios all significantly decreased from Type S to Type D. However, VLDL-C/VLDL-TG was not different among the groups. Conclusion SAND classification of lipoprotein profile may offer a new clinical tool to cover the weak point of WHO classification.(Internal Medicine 42: 244-249, 2003)
- 社団法人 日本内科学会の論文
- 2003-03-01
著者
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Nomura H
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Nomura Hideki
Department Of Cell Physiology Nagoya University Graduate School Of Medicine
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Kodama Michiteru
Department of Geriatrics, Nagoya University Graduate School of Medicine
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NAITO Michitaka
Division of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen Univer
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Yoshida Akihiro
Department Of Biology Faculty Of Science Kyushu University
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Kodama Michiteru
Department Of Geriatrics Nagoya University Graduate School Of Medicine
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Naito Michitaka
Division Of Nutrition & Health School And Graduate School Of Life Studies Sugiyama Jogakuen Univ
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Yoshida Akihiro
Department Of Clinical Laboratory Nakatsugawa Municipal Hospital
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Yoshida Akihiro
Department Of Applied Physics Faculty Of Science Fukuoka University
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