A Novel Labdane-Type Trialdehyde from Myoga (Zingiber mioga Roscoe) That Potently Inhibits Human Platelet Aggregation and Human 5-Lipoxygenase

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概要

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• We screened myoga extracts for inhibitors of human platelet aggregation and human 5-lipoxygenase. We identified a novel labdane type of diterpene, together with three known diterpenes (miogadial and galanals A and B) from the flower buds of myoga. Spectroscopic data indicated the structure of the new compound to be 12(E)-labdene-15,16,(8β)17-trial (miogatrial). Miogatrial and miogadial were potent inhibitors of human platelet aggregation and human 5-lipoxygenase (5-LOX). The sesquiterpene, polygodial, also exhibited strong inhibitory activity against human platelet aggregation and 5-LOX. On the other hand, galanals A and B did not have inhibitory activity in either experimental system. It thus appears that a 3-formyl-3-butenal structure was essential for the potent inhibition of human platelet aggregation and human 5-LOX.

• 社団法人 日本農芸化学会の論文
• 2006-10-23

著者

• OSAWA Toshihiko

  Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University

• 大沢 俊彦

  名古屋大学大学院生命農学研究科

• NAKAMURA Yoshimasa

  Department of Food Science and Technology, Faculty of Agriculture, Kyoto University

• Nakamura Yoko

  Laboratory Of Biological Chemistry Graduate School Of Agricultural And Life Science University Of To

• Abe M

  Gakushuin Women's Coll. Tokyo Jpn

• Nakamura Y

  Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And

• Osawa T

  Nagoya University Graduate School Of Bioagricultural Sciences

• Osawa Toshihiko

  Lab. Of Food And Biodynamics Graduate School Of Bioagricultural Sciences Nagoya Univ.

• Osawa T

  Laboratory Of Food And Biodynamics Nagoya University Graduate School Of Bioagricultural Sciences

• Osawa Toshihiko

  Department Of Food Science And Technology Faculty Of Agriculture Nagoya University

• Osawa T

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Nakamura Yoshimasa

  Department Of Biofunctional Chemistry Division Of Bioscience Graduate School Of Natural Science And

• 森光 康次郎

  お茶の水女子大学

• ABE Masako

  Department of Health and Nutrition, Takasaki University of Health and Welfare

• OZAWA Yoshio

  Department of Health and Nutrition, Takasaki University of Health and Welfare

• UDA Yasushi

  Department of Bioproductive Sciences, Utsunomiya University

• MORIMITSU Yasujiro

  Laboratory of Food Chemistry, Graduate School of Humanities and Sciences, Ochanomizu University

• Uda Yasushi

  Department Of Bioproductive Sciences Faculty Of Agriculture Utsunomiya University

• Uda Y

  Niigata Coll. Niigata Jpn

• Uda Yasushi

  Department Of Agricultural Chemistry Utsunomiya University

• Ozawa Yoshio

  Department Of Health And Nutrition Takasaki University Of Health And Welfare

• 大沢 俊彦

  名古屋大学 生命農研究

• 森三 康次郎

  お茶の水女子大学

• Morimitsu Yasujiro

  Lab. Of Food Chemistry Dep. Of Nutrition & Food Sci. Ochanomizu Univ.

• Morimitsu Yasujiro

  Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka

• Morimitsu Yasujiro

  Laboratory Of Applied Microbiology School Of Food And Nutritional Sciences University Of Shizuoka:la

• Morimitsu Y

  Department Of Food And Nutritional Sciences Graduate School Of Humanities And Sciences Ochanomizu Un

• Osawa Toshihiko

  Laboratory Of Food And Biodynamics Graduate School Of Bioagricultural Sciences Nagoya University

• Osawa Toshihiko

  Laboratory Of Food And Bio-dynamics Nagoya University

• 大澤 俊彦

  名古屋大学農学部応用生物科学科食品機能化学研究室

• Abe Masako

  Department Of Clinical Genetics Medical Institute Of Bioregulation Kyushu University

• Nakamura Yoshimasa

  Department Of Applied Mathematics And Physics Faculty Of Engineering Kyoto University

• Morimitsu Yasujiro

  Graduate School Of Humanities And Lab. Of Food Chemistry Ochanomizu Univ.

• Morimitsu Yasujiro

  Laboratory Of Food Chemistry Faculty Of Humanities And Sciences Ochanomizu University

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