Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans
スポンサーリンク
概要
- 論文の詳細を見る
The concentrations of metabolites in human plasma after ingestion of flavanone glycosides (FG) and their aglycones (FA) in lemon were examined. FG consisting abundantly of eriocitrin were prepared from lemon peel and FA consisting abundantly of eriodictyol were prepared from FG by treatment with β-glucosidase. Eriodictyol, homoeriodictyol, and hesperetin in plasma up to 4 h after ingestion of FG with water or FA with water by subjects were not detected in plasma of non-enzyme treatment but in plasma after treatment with β-glucronidase and sulfatase. Metabolites in plasma after ingestion of FG and FA in humans were shown to exist as the glucuro- and/or sulfo-conjugates of eriodictyol, homoeriodictyol, and hesperetin. After ingestion of FA, the concentration of metabolites in plasma exhibited a high maximum peak at 1 h. The AUC (area under the blood concentration time curve) level of metabolites of FA was higher than that of FG. FA were suggested to be absorbed faster and in higher amounts than FG. The AUC of metabolites in subject plasma after ingestion of FG with flavonoid-depleted lemon juice was shown to change to a low level in comparison with that of FG with water. The maximum concentration peak of metabolites in plasma was faster at 0.5 h than FA with water but the AUC level was similar to FA with water, when subjects ingested FA with vodka (40% ethanol). The absorption hour of FG and FA was shown to be affected by the co-existing solution.
- 日本ビタミン学会の論文
著者
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MIYAKE Yoshiaki
Faculty of Human Wellness, Tokaigakuen University
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OSAWA Toshihiko
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University
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大沢 俊彦
名古屋大学大学院生命農学研究科
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Usuda Mika
Institute Of Environmental Science For Human Life Ochanomizu University
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Fukumoto Syuichi
Pokka Corporation
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KONDO Kazuo
Institute of Environmental Science for Human Life, Ochanomizu University
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Kondo Kazuo
Institute Of Environmental Science For Human Life Ochanomizu University
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Osawa T
Nagoya University Graduate School Of Bioagricultural Sciences
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Osawa Toshihiko
Lab. Of Food And Biodynamics Graduate School Of Bioagricultural Sciences Nagoya Univ.
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Osawa T
Laboratory Of Food And Biodynamics Nagoya University Graduate School Of Bioagricultural Sciences
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Osawa Toshihiko
Department Of Food Science And Technology Faculty Of Agriculture Nagoya University
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Osawa T
Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.
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Miyake Y
Central Research Laboratory Of Pokka Corporation Ltd.
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SAKURAI Chika
Institute of Environmental Science for Human Life, Ochanomizu University
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HIRAMITSU Masanori
Pokka Corporation Ltd.
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SAKAIDA Kazuhiro
Pokka Corporation Ltd.
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Sakurai Chika
Institute Of Environmental Science For Human Life Ochanomizu University
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Miyake Yayoi
Faculty Of Human Wellness Tokaigakuen University
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Miyake Yoshiaki
Faculty Of Human Wellness Tokaigakuen University
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Kondo Kazuo
Natural/applied Sciences Div. Graduate School Of Humanities And Sciences Ochanomizu Univ.
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大沢 俊彦
名古屋大学 生命農研究
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Fukumoto Syuichi
Pokka Corporation Ltd.
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Osawa Toshihiko
Laboratory Of Food And Biodynamics Graduate School Of Bioagricultural Sciences Nagoya University
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Osawa Toshihiko
Laboratory Of Food And Bio-dynamics Nagoya University
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大澤 俊彦
名古屋大学農学部応用生物科学科食品機能化学研究室
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Sakaida Kazuhiro
Pokka Corp. Ltd. Aichi Jpn
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