The Coantioxidative Effects of Carboxyethyl-6-Hydroxychromans and α-Tocopherol

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概要

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• α-Tocopherol (α-Toc) is abundant in LDL and thought to prevent the oxidation of LDL together with various water-soluble antioxidants. Recently, it was reported that α-Toc and γ-Toc metabolites, α-carboxyethyl-6-hydroxychromans (CEHC) and γ-CEHC, are water-soluble antioxidants. In this study, we investigated the interaction between α-Toc and CEHC against 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and LDL oxidation. We administered 600mg of α-Toc to healthy male volunteers to obtain LDL including high levels of α-Toc before antioxidant administration. The α-Toc content of their LDL was increased after consumption at 24h (18.3μg/mL) above the level before consumption (6.6μg/mL). The lag time of LDL at 24h after α-Toc consumption (α-Toc rich LDL) with α-CEHC (98.5±8.2min) or γ-CEHC (101.3±9.0min) was longer than that of only α-Toc-rich LDL (78.1±9.0 min). Furthermore, we examined the interaction of LDL with CEHC and α-Toc in vitro (5-20μg/mL). The lag times of 5 and 10μg/mL α-Toc were 65.5±18.9 min and 69.5±15.5 min, and that of 20 μg/mL α-Toc (83.5±20.2 min) was longer than the control value (55.7±14.1 min). The lag time of 20 μg/mL α-Toc with α-CEHC (98.7±25.7min) or γ-CEHC (100.6±25.3min) was longer than that of only α-Toc (83.5±20.2min). These results suggest that CEHC has the potential to delay the oxidation of LDL, while enhancing the antioxidative activity of α-Toc both in vitro and ex vivo.

• 日本ビタミン学会の論文

著者

• KONDO Kazuo

  Institute of Environmental Science for Human Life, Ochanomizu University

• Kondo Kazuo

  長野県工業技術総合センター 食品技術部門加工食品部

• Kondo Kazuo

  Institute Of Environmental Science For Human Life Ochanomizu University

• Ohmori Reiko

  Faculty Of Education Utsunomiya University

• IGARASHI Osamu

  Department of Industrial Chemistry, Faculty of Engineering, Seikei University

• UTO Harumi

  Institute of Environmental Science for Human Life, Ochanomizu University

• Uto H

  Institute Of Environmental Science For Human Life Ochanomizu University

• Igarashi O

  Department Of Life Science Ibaraki Christian University

• Igarashi O

  Ibaraki Christian Univ. Hitachi Jpn

• Igarashi Osamu

  Joining And Welding Research Institute Osaka University

• Hasegawa Maiko

  Institute Of Environmental Science For Human Life Ochanomizu University

• Kojima Keiichi

  Division Of Healthcare Science Central Research Laboratory The Nisshin Oillio Group Ltd.

• Kondo K

  Institute Of Environmental Science For Human Life Ochanomizu University

• UTO-KONDO Harumi

  Institute of Environmental Science for Human Life, Ochanomizu University

• KIYOSE Chikako

  Department of Engineering, Kanagawa Institute of Technology

• SAITO Hisako

  Faculty of Education, Hirosaki University

• TAGUCHI Chie

  Institute of Environmental Science for Human Life, Ochanomizu University

• KISHIMOTO Yoshimi

  Institute of Environmental Science for Human Life, Ochanomizu University

• MACHIDA Naoko

  Institute of Environmental Science for Human Life, Ochanomizu University

• YOSHIOKA Eri

  Institute of Environmental Science for Human Life, Ochanomizu University

• SAIAT Emi

  Institute of Environmental Science for Human Life, Ochanomizu University

• HIRATA Yumiko

  Institute of Environmental Science for Human Life, Ochanomizu University

• Saiat Emi

  Institute Of Environmental Science For Human Life Ochanomizu University

• Taguchi Chie

  Institute Of Environmental Science For Human Life Ochanomizu University

• Saito Hisako

  Faculty Of Education Hirosaki University

• Yoshioka Eri

  Institute Of Environmental Science For Human Life Ochanomizu University

• Hirata Yumiko

  Institute Of Environmental Science For Human Life Ochanomizu University

• Machida Naoko

  Institute Of Environmental Science For Human Life Ochanomizu University

• Kiyose Chikako

  Department Of Engineering Kanagawa Institute Of Technology

• Igarashi Osamu

  Department Of Food & Health School Of Life Science Ibaraki Christian University

• Uto-kondo Harumi

  Institute Of Environmental Science For Human Life Ochanomizu University

• Kishimoto Yoshimi

  Institute Of Environmental Science For Human Life Ochanomizu University

• Saita Emi

  Institute Of Environmental Science For Human Life Ochanomizu University

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